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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SMC1A Antibody Picoband®

SKU : BHA21004868

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Mfr.No.	A02148-5, A02148-5-10ug, A02148-5-Biotin, A02148-5-Cy3, A02148-5-Dylight488, A02148-5-Dylight550, A02148-5-Dylight594, A02148-5-FITC, A02148-5-HRP, A02148-5-APC, A02148-5-PE, A02148-5-iFluor647, A02148-5-carrier-free
Alternative Names	mucin 6, oligomeric mucus/gel-forming
Background	Structural maintenance of chromosomes protein 1A (SMC1A) is a protein that in humans is encoded by the SMC1A gene. Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Coelia de Lange syndrome. Alteative splicing results in multiple transcript variants encoding different isoforms.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SMC1A Antibody Picoband® catalog # A02148-5. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are use
Host	Rabbit
Immunogen Region	E.coli-derived human SMC1A recombinant protein (Position: K59-Q1233).
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Mucin-6; MUC-6; Gastric mucin-6; MUC6
Tissue Specificity	Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q14683
Gene Id	8243
Gene Name	SMC1A
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Brown, C. J., Miller, A. P., Carrel, L., Rupert, J. L., Davies, K. E., Willard, H. F. The DXS423E gene in Xp11.21 escapes X chromosome inactivation. Hum. Molec. Genet. 4: 251-255, 1995. 2. Davidson, I. F., Bauer, B., Goetz, D., Tang, W., Wutz, G., Peters, J. M. DNA loop extrusion by human cohesin. Science 366: 1338-1345, 2019. 3. Deardorff, M. A., Kaur, M., Yaeger, D., Rampuria, A., Korolev, S., Pie, J., Gil-Rodriguez, C., Aedo, M., Loeys, B., Kline, A. D., Wilson, M., Lillquist, K., Siu, V., Ramos, F. J., Musio, A., Jackson, L. S., Dorsett, D., Krantz, I. D. Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of Coelia de Lange syndrome with predominant mental retardation. Am. J. Hum. Genet. 80: 485-494, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004868-1	A02148-5	-	100 ug	$370		Add to Cart
BHA21004868-2	A02148-5-10ug	Sample	10 ug	$99		Add to Cart
BHA21004868-3	A02148-5-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004868-4	A02148-5-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004868-5	A02148-5-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004868-6	A02148-5-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004868-7	A02148-5-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004868-8	A02148-5-FITC	FITC	100 ug	$570		Add to Cart
BHA21004868-9	A02148-5-HRP	HRP	100 ug	$570		Add to Cart
BHA21004868-10	A02148-5-APC	APC	100 ug	$670		Add to Cart
BHA21004868-11	A02148-5-PE	PE	100 ug	$670		Add to Cart
BHA21004868-12	A02148-5-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004868-13	A02148-5-carrier-free	carrier-free	100 ug	$370		Add to Cart

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