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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SMAD5 Antibody Picoband®

SKU : BHA21007320

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Mfr.No.	PA2115, PA2115-10ug, PA2115-Biotin, PA2115-Cy3, PA2115-Dylight488, PA2115-Dylight550, PA2115-Dylight594, PA2115-FITC, PA2115-HRP, PA2115-APC, PA2115-PE, PA2115-iFluor647, PA2115-carrier-free
Alternative Names	Mothers against decapentaplegic homolog 5
Background	Mother against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SAMD5 gene. It belongs to the SMAD family of proteins, which belong to the TGFbeta superfamily of modulators. The gene was assigned to human chromosome 5q31. Like many other TGFbeta family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). It may play a role in the pathway where TGFbeta is an inhibitor of hematopoietic progenitor cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SMAD5 Antibody catalog # PA2115. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human SMAD5, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	52 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Mothers against decapentaplegic homolog 5;MAD homolog 5;Mothers against DPP homolog 5;JV5-1;SMAD family member 5;SMAD 5;Smad5;hSmad5;SMAD5;MADH5;
Tissue Specificity	Ubiquitous.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q99717
Gene Name	SMAD5
Sequence	Belongs to the dwarfin/SMAD family.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Bruno, E., Horrigan, S. K., Van Den Berg, D., Rozler, E., Fitting, P. R., Moss, S. T., Westbrook, C., Hoffman, R. The Smad5 gene is involved in the intracellular signaling pathways that mediate the inhibitory effects of transforming growth factor-beta on human hematopoiesis. Blood 91: 1917-1923, 1998.<br /><br />2. Davis, B. N., Hilyard, A. C., Lagna, G., Hata, A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454: 56-61, 2008.<br /><br />3. Gemma, A., Hagiwara, K., Vincent, F., Ke, Y., Hancock, A. R., Nagashima, M., Bennett, W. P., Harris, C. C. hSmad5 gene, a human hSmad family member: its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors. Oncogene 16: 951-956, 1998.<br /><br />4. Riggins, G. J., Thiagalingam, S., Rozenblum, E., Weinstein, C. L., Ke, S. E., Hamilton, S. R., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W., Vogelstein, B. Mad-related genes in the human. Nature Genet. 13: 347-349, 1996.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007320-1	PA2115	-	100 ug	$370		Add to Cart
BHA21007320-2	PA2115-10ug	Sample	10 ug	$99		Add to Cart
BHA21007320-3	PA2115-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007320-4	PA2115-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007320-5	PA2115-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007320-6	PA2115-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007320-7	PA2115-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007320-8	PA2115-FITC	FITC	100 ug	$570		Add to Cart
BHA21007320-9	PA2115-HRP	HRP	100 ug	$570		Add to Cart
BHA21007320-10	PA2115-APC	APC	100 ug	$670		Add to Cart
BHA21007320-11	PA2115-PE	PE	100 ug	$670		Add to Cart
BHA21007320-12	PA2115-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007320-13	PA2115-carrier-free	carrier-free	100 ug	$370		Add to Cart

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