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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Smad4 Antibody Picoband®

SKU : BHA21000273

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Mfr.No.	PB9397, PB9397-10ug, PB9397-Biotin, PB9397-Cy3, PB9397-Dylight488, PB9397-Dylight550, PB9397-Dylight594, PB9397-FITC, PB9397-HRP, PB9397-APC, PB9397-PE, PB9397-iFluor647, PB9397-carrier-free
Alternative Names	Mothers against decapentaplegic homolog 4
Background	SMAD4 (Mothers Against Decapentaplegic Drosophila Homolog of 4), also known as MADH4 or DPC4, is a protein that in humans is encoded by the SMAD4 gene. It belongs to the Darfwin family of proteins that modulate members of the TGFbeta protein superfamily. Hahn et al. (1996) identified the SMAD4 gene on chromosome 18q21.1. Howe et al. (1998) identified the SMAD4 gene within a region on 18q21.1 defined by linkage analysis in kindred with juvenile polyposis syndrome. To test ly the hypothesis that the SMAD4 gene is a tumor suppressor that is critical for transmitting signals from transforming growth factor-beta and related ligands. SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Smad4 Antibody Picoband® catalog # PB9397. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to pr
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Smad4, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Mothers against decapentaplegic homolog 4;MAD homolog 4;Mothers against DPP homolog 4;Deletion target in pancreatic carcinoma 4;SMAD family member 4;SMAD 4;Smad4;hSMAD4;SMAD4;DPC4, MADH4;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q13485
Gene Id	4089
Gene Name	SMAD4
Sequence	Belongs to the dwarfin/SMAD family.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R- SMAD. PDPK1 prevents its nuclear translocation in response to TGF- beta.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. Hein, L.; Altman, J. D.; Kobilka, B. K. :Two functionally distinct alpha-2-adrenergic receptors regulate sympathetic neurotransmission. Nature 402: 181-184, 1999. 2. Hoehe, M. R.; Berrettini, W. H.; Lentes, K.-U.:Dra I identifies a two allele DNA polymorphism in the human alpha-2-adrenergic receptor gene (ADRAR), using a 5.5 kb probe (p ADRAR). Nucleic Acids Res. 16: 9070 only, 1988. 3. Yang-Feng, T. L.; Kobilka, B. K.; Caron, M. G.; Lefkowitz, R. J.; Francke, U.:Chromosomal assignment of genes for an alpha-adrenergic receptor (ADRAR) and for another member of this receptor family coupled to guanine nucleotide regulatory proteins (RG21). (Abstract) Cytogenet. Cell Genet. 46: 722-723, 1987.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000273-1	PB9397	100 ug	-	$370		Add to Cart
BHA21000273-2	PB9397-10ug	10 ug	Sample	$99		Add to Cart
BHA21000273-3	PB9397-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000273-4	PB9397-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000273-5	PB9397-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000273-6	PB9397-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000273-7	PB9397-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000273-8	PB9397-FITC	100 ug	FITC	$570		Add to Cart
BHA21000273-9	PB9397-HRP	100 ug	HRP	$570		Add to Cart
BHA21000273-10	PB9397-APC	100 ug	APC	$670		Add to Cart
BHA21000273-11	PB9397-PE	100 ug	PE	$670		Add to Cart
BHA21000273-12	PB9397-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000273-13	PB9397-carrier-free	100 ug	carrier-free	$370		Add to Cart

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