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Home / Primary Antibodies / Polyclonal Antibodies

Anti-slobeta3 (KCNMB3) (extracellular) Antibody

SKU : BHA21300992

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Alomone Labs

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Mfr.No.	APC-068, APC-068-CF_0.2 ml, APC-068_0.2 ml, APC-068_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	Large-conductance, voltage- and Ca2+-activated K+ channels, also known as the BK channels, are widely expressed channels that couple changes in submembrane Ca2+ concentration to the regulation of electrical excitability1. BK channels are formed from four alpha-subunits arising from the Slowpoke (Slo) gene product2. In addition, in smooth muscle and cochlea, an accessory beta-subunit can regulate BK channel gating profoundly. At present, four beta subunits have been cloned in mammals. beta subunits alter the Ca2+ sensitivity and gating kinetics of BK channels, greatly contributing to BK channel diversity. On the other hand, they modify the BK channel pharmacological properties, changing toxin binding and acting as receptors for drugs3.Regulatory beta subunits share a putative membrane topology, with two transmembrane segments connected by a 120- residue extracellular loop and with NH2 and COOH terminals oriented toward the cytoplasm4. Each beta subunit has a tissue-specific expression and modulates channel function uniquely which provides a major mechanism for diverse BK channel phenotypes in various tissues.beta3 is highly expressed in kidney, heart, and brain5. The beta3 gene (KCNMB3) associates with Slo1 alpha subunits and regulate BK channel function. In humans, the beta3 gene contains four N-terminal alternative exons that produce four functionally distinct beta3 subunits, beta3a-d. Three variants, beta3a-c, exhibit kinetically distinct inactivation behaviors6. A mutation in the beta3 gene is linked to idiopathic epilepsy7.
Clonality	Polyclonal
Description	Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of rat slobeta3. Anti-slobeta3 (KCNMB3) (extracellular) Antibody (#APC-068) can be used in western blot analysis. It has been designed to recognize slobeta3 from rat and mouse samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	Extracellular loop
Isotype	Rabbit IgG
Reactivity	Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Ca2+-activated K+ channel subunit beta3, BKCa beta3, BK beta 3, Maxi K channel beta3, Charybdotoxin receptor subunit beta-3
UNSPSC Code	41116161
Note	Homology: Mouse - 11/12 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-PC068 Specifictiy: KCNMB3 AB Specifictiy: Not recommended for human samples. Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	A7VL23
Gene Id	310303
Target	Ca2+-activated K+ channel subunit beta3, BKCa beta3, BK beta 3, Maxi K channel beta3, Charybdotoxin receptor subunit beta-3
Sequence	(C)HYDEEAIRTNPK, corresponding to amino acid residues 134-145 of rat KCNMB3

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IHC, WB
Dilution	1:300

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300992-1	APC-068-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21300992-2	APC-068_0.2 ml	0.2 ml	$795		Add to Cart
BHA21300992-3	APC-068_50 mcl	50 mcl	$697		Add to Cart

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