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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SLFN11 Antibody Picoband®

SKU : BHA21003382

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Mfr.No.	A08259, A08259-10ug, A08259-Biotin, A08259-Cy3, A08259-Dylight488, A08259-Dylight550, A08259-Dylight594, A08259-FITC, A08259-HRP, A08259-APC, A08259-PE, A08259-iFluor647, A08259-carrier-free
Alternative Names	neuropeptides B and W receptor 1
Background	Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. SLFN11 is a nuclear protein that belongs to the Schlafen (SLFN) family of genes involved in cell cycle regulation and growth inhibition. Expression of SLFN11 predicts sensitivity of cancer cell lines to DNA-damaging agents. Evidence suggests that in the presence of DNA-targeted therapies, SLFN11 is recruited to stressed replication forks where it blocks replication leading to cell death. SLFN11 is being explored as a predictive biomarker for response to DNA-targeted therapies.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SLFN11 Antibody Picoband® catalog # A08259. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.
Host	Rabbit
Immunogen Region	E.coli-derived human SLFN11 recombinant protein (Position: P114-D794).
Isotype	Rabbit IgG
Molecular Weight	103 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Neuropeptides B/W receptor type 1; G-protein coupled receptor 7; NPBWR1; GPR7
Tissue Specificity	Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Uniprot	Q7Z7L1
Gene Id	91607
Gene Name	SLFN11
Subcellular Location	Cell membrane. Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Bustos, O., Naik, S., Ayers, G., Casola, C., Perez-Lamigueiro, M. A., Chippindale, P. T., Pritham, E. J., de la Casa-Esperon, E. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes, and orthopoxvirus virulence. Gene 447: 1-11, 2009.<br /><br />2. Geserick, P., Kaiser, F., Klemm, U., Kaufmann, S. H. E., Zerrahn, J. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int. Immun. 16: 1535-1548, 2004. <br /><br />3. Gross, M. B. Personal Communication. Baltimore, Md. 11/29/2012.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003382-1	A08259	-	100 ug	$370		Add to Cart
BHA21003382-2	A08259-10ug	Sample	10 ug	$99		Add to Cart
BHA21003382-3	A08259-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003382-4	A08259-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003382-5	A08259-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003382-6	A08259-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003382-7	A08259-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003382-8	A08259-FITC	FITC	100 ug	$570		Add to Cart
BHA21003382-9	A08259-HRP	HRP	100 ug	$570		Add to Cart
BHA21003382-10	A08259-APC	APC	100 ug	$670		Add to Cart
BHA21003382-11	A08259-PE	PE	100 ug	$670		Add to Cart
BHA21003382-12	A08259-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003382-13	A08259-carrier-free	carrier-free	100 ug	$370		Add to Cart

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