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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SLC10A1/NTCP1 Antibody Picoband®

SKU : BHA21002622

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Mfr.No.	A06872, A06872-10ug, A06872-Biotin, A06872-Cy3, A06872-Dylight488, A06872-Dylight550, A06872-Dylight594, A06872-FITC, A06872-HRP, A06872-APC, A06872-PE, A06872-iFluor647, A06872-carrier-free
Alternative Names	solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Background	Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene. It is mapped to 12 C3-D1; 12 37.21 cM. The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SLC10A1/NTCP1 Antibody Picoband® catalog # A06872. Tested in WB applications. This antibody reacts with Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of mouse SLC10A1/NTCP1, identical to the related rat sequence.
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Sodium/bile acid cotransporter; Na (+)/bile acid cotransporter; Na (+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1; Slc10a1; Ntcp
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	O08705
Gene Id	20493
Gene Name	Slc10a1
Subcellular Location	Membrane. Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.25-0.5ug/ml, Rat<br>

Reference	1. Green, R. M., Ananthanarayanan, M., Suchy, F. J., Beier, D. R. Genetic mapping of the Na(+)-taurocholate cotransporting polypeptide to mouse chromosome 12. Mammalian Genome 9: 598-600, 1998.<br /><br />2. Hagenbuch, B., Meier, P. J. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na(+)/bile acid cotransporter. J. Clin. Invest. 93: 1326-1331, 1994.<br /><br />3. Hallen, S., Mareninova, O., Branden, M., Sachs, G. Organization of the membrane domain of the human liver sodium/bile acid cotransporter. Biochemistry 41: 7253-7266, 2002.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002622-1	A06872	-	100 ug	$370		Add to Cart
BHA21002622-2	A06872-10ug	Sample	10 ug	$99		Add to Cart
BHA21002622-3	A06872-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002622-4	A06872-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002622-5	A06872-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002622-6	A06872-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002622-7	A06872-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002622-8	A06872-FITC	FITC	100 ug	$570		Add to Cart
BHA21002622-9	A06872-HRP	HRP	100 ug	$570		Add to Cart
BHA21002622-10	A06872-APC	APC	100 ug	$670		Add to Cart
BHA21002622-11	A06872-PE	PE	100 ug	$670		Add to Cart
BHA21002622-12	A06872-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002622-13	A06872-carrier-free	carrier-free	100 ug	$370		Add to Cart

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