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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SLC10A1 Antibody Picoband®

SKU : BHA21000643

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Mfr.No.	PB9745, PB9745-10ug, PB9745-Biotin, PB9745-Cy3, PB9745-Dylight488, PB9745-Dylight550, PB9745-Dylight594, PB9745-FITC, PB9745-HRP, PB9745-APC, PB9745-PE, PB9745-iFluor647, PB9745-carrier-free
Alternative Names	Sodium/bile acid cotransporter
Background	Na+-taurocholate cotransporting polypeptide (NTCP), also known as SLC10A1 (Solute carrier family 10, member 1), is the major bile acid uptake system in human hepatocytes. NTCP and the ileal transporter ASBT (apical sodium-dependent bile acid transporter) are two sodium-dependent transporters critical for the enterohepatic circulation of bile acids. The hASBT gene is known to be activated by the glucocorticoid receptor (GR). Ho RH et al. indicates functionally important polymorphisms in NTCP exist and that the like lihood of being carriers of such polymorphisms is dependent on ethnicity.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SLC10A1 Antibody Picoband® catalog # PB9745. Tested in Flow Cytometry, IF, IHC, IHC-F, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of mouse SLC10A1, different from the related human sequence by eighteen amino acids, and from the related rat sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Sodium/bile acid cotransporter;Na (+)/bile acid cotransporter;Na (+)/taurocholate transport protein;Sodium/taurocholate cotransporting polypeptide;Solute carrier family 10 member 1;Slc10a1;Ntcp;
Tissue Specificity	Predominantly expressed in the brain.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	O08705
Gene Id	20493
Gene Name	Slc10a1
Subcellular Location	Membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, IHC-F, WB
Description	Weste blot, 0.1-0.5ug/ml Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, By Heat Immunohistochemistry (Frozen Section), 0.5-1ug/ml Immunofluorescence, 2ug/ml Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells

Reference	1. Eloranta JJ, Jung D, Kullak-Ublick GA (2006). "The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism.". Mol. Endocrinol. 20 (1): 6579. 2. Ho RH, Leake BF, Roberts RL, et al. (2004). "Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition.". J. Biol. Chem. 279 (8): 721322.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000643-1	PB9745	100 ug	-	$370		Add to Cart
BHA21000643-2	PB9745-10ug	10 ug	Sample	$99		Add to Cart
BHA21000643-3	PB9745-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000643-4	PB9745-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000643-5	PB9745-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000643-6	PB9745-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000643-7	PB9745-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000643-8	PB9745-FITC	100 ug	FITC	$570		Add to Cart
BHA21000643-9	PB9745-HRP	100 ug	HRP	$570		Add to Cart
BHA21000643-10	PB9745-APC	100 ug	APC	$670		Add to Cart
BHA21000643-11	PB9745-PE	100 ug	PE	$670		Add to Cart
BHA21000643-12	PB9745-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000643-13	PB9745-carrier-free	100 ug	carrier-free	$370		Add to Cart

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