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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SKA2 Antibody Picoband®

SKU : BHA21002430

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Mfr.No.	A06326, A06326-10ug, A06326-Biotin, A06326-Cy3, A06326-Dylight488, A06326-Dylight550, A06326-Dylight594, A06326-FITC, A06326-HRP, A06326-APC, A06326-PE, A06326-iFluor647, A06326-carrier-free
Alternative Names	spindle and kinetochore associated complex subunit 2
Background	Spindle and kinetochore-associated protein 2 is a protein that in humans is encoded by the SKA2 gene found in chromosome 17.SKA2 is a part of a spindle and kinetochore associated complex also including SKA1 and SKA3 which is responsible for onset of the anaphase in mitosis by regulating chromosomal segregation. SKA2 may function as a prognostic gene marker for identifying lung cancer(3) as well as a proposed biomarker for suicidal tendencies and post-traumatic stress disorders.(4)(5) The SKA2 gene contains one single-nucleotide polymorphism (SNP) rs7208505 located in the 3' UTR. This genetic variant containing a cytosine (existing in the less common allele) instead of thymine along with epigenetic modification (such as DNA methylation) is correlated with suicidal tendencies and post-traumatic stress
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SKA2 Antibody Picoband® catalog # A06326. Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chrom
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human SKA2, which shares 90.0% amino acid (aa) sequence identity with both mouse and rat SKA2.
Isotype	Rabbit IgG
Molecular Weight	20 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Spindle and kinetochore-associated protein 2; Protein FAM33A; SKA2; FAM33A
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q8WVK7
Gene Id	348235
Gene Name	SKA2
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, WB
Description	"Weste blot, 0.25-0.5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>"

Reference	1. Hanisch A, Silljé HH, Nigg EA (November 2006). "Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2". The EMBO Joual. 25 (23): 550415.<br /><br />2. Wang Y, Zhang Y, Zhang C, Weng H, Li Y, Cai W, Xie M, Long Y, Ai Q, Liu Z, Du G, Wang S, Niu Y, Song F, Ozaki T, Bu Y (September 2015). "The gene pair PRR11 and SKA2 shares a NF-Y-regulated biional promoter and contributes to lung cancer development". Biochimica et Biophysica Acta. 1849 (9): 113344. <br /><br />3. Guintivano J, Brown T, Newcomer A, Jones M, Cox O, Maher BS, Eaton WW, Payne JL, Wilcox HC, Kaminsky ZA (December 2014). "Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors". The American Joual of Psychiatry. 171 (12): 128796.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002430-1	A06326	-	100 ug	$370		Add to Cart
BHA21002430-2	A06326-10ug	Sample	10 ug	$99		Add to Cart
BHA21002430-3	A06326-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002430-4	A06326-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002430-5	A06326-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002430-6	A06326-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002430-7	A06326-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002430-8	A06326-FITC	FITC	100 ug	$570		Add to Cart
BHA21002430-9	A06326-HRP	HRP	100 ug	$570		Add to Cart
BHA21002430-10	A06326-APC	APC	100 ug	$670		Add to Cart
BHA21002430-11	A06326-PE	PE	100 ug	$670		Add to Cart
BHA21002430-12	A06326-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002430-13	A06326-carrier-free	carrier-free	100 ug	$370		Add to Cart

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