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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SIRT2 Antibody Picoband®

SKU : BHA21000050

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Mfr.No.	PB9160, PB9160-10ug, PB9160-Biotin, PB9160-Cy3, PB9160-Dylight488, PB9160-Dylight550, PB9160-Dylight594, PB9160-FITC, PB9160-HRP, PB9160-APC, PB9160-PE, PB9160-iFluor647, PB9160-carrier-free
Alternative Names	NAD-dependent protein deacetylase sirtuin-2
Background	SIRT2 is a predominantly cytoplasmic protein that colocalizes with microtubules. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT2 is mapped to 19q13.2. It is able to cause radioactivity to be transferred from (32P) NAD to bovine serum albumin (BSA). According to researches, SIRT2 can act as a bona fide tubulin deacetylase. SIRT2 was found to deacetylate lys40 of alpha-tubulin both in vitro and in vivo. SIRT2 is also a regulator of mitotic progression that acts downstream from CDC14B in a pathway regulating mitotic exit or subsequent cytokinesis. What s more, SIRT2 is an important regulator of programmed necrosis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SIRT2 Antibody Picoband® catalog # PB9160. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	NAD-dependent protein deacetylase, which deacetylates inteal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human SIRT2, different from the related mouse and rat sequences by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	36 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	NAD-dependent protein deacetylase sirtuin-2;3.5.1.-;Regulatory protein SIR2 homolog 2;SIR2-like protein 2;SIRT2;SIR2L, SIR2L2;
Tissue Specificity	Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q8IXJ6
Gene Id	22933
Gene Name	SIRT2
Sequence	Belongs to the sirtuin family. Class I subfamily.
Subcellular Location	Nucleus. Cytoplasm, perinuclear region. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Perikaryon . Cell projection . Cell projection, growth cone . Myelin membrane . Deacetylates FOXO3 in the cytoplasm. Colocalizes with PLP1 in inteodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat. Colocalizes with CDK5R1 in the perikaryon, neurites and growth cone of hippocampal neurons. Colocalizes with alpha-tubulin in neuronal growth cone. Localizes in the cytoplasm and nucleus of germinal vesicle (GV) stage oocytes. Colocalizes with alpha- tubulin on the meiotic spindle as the oocytes enter into metaphase, and also during meiotic anaphase and telophase, especially with the midbody. Colocalizes with PARD3 in inteodal region of axons. Colocalizes with acetylated alpha-tubulin in cell projection processes during primary oligodendrocyte precursor (OLP) differentiation (By similarity). Localizes in the cytoplasm during most of the cell cycle except in the G2/M transition and during mitosis, where it is localized in association with chromatin and induces deacetylation of histone at 'Lys-16' (H4K16ac). Colocalizes with SETD8 at mitotic foci. Colocalizes with CDK1 at centrosome during prophase and splindle fibers during metaphase. Colocalizes with Aurora kinase AURKA at centrosome during early prophase and in the centrioles and growing mitotic spindle throughout metaphase. Colocalizes with Aurora kinase AURKB during cytokinesis with the midbody. Colocalizes with microtubules. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Colocalizes with EP300 in the nucleus. Translocates to the nucleus and chromatin upon bacterium Listeria monocytogenes infection in interphase cells. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Human, Rat

Reference	1. Dryden, S. C., Nahhas, F. A., Nowak, J. E., Goustin, A.-S., Tainsky, M. A. Role for humanSIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Molec. Cell Biol. 23: 3173-3185, 2003. 2. "Entrez Gene: SIRT2 sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)" 3. North, B. J., Marshall, B. L., Borra, M. T., Denu, J. M., Verdin, E. The human Sir2 ortholog, SIRT2, is an NAD(+)-dependent tubulin deacetylase. Molec. Cell 11: 437-444, 2003.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000050-1	PB9160	100 ug	-	$370		Add to Cart
BHA21000050-3	PB9160-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000050-4	PB9160-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000050-5	PB9160-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000050-6	PB9160-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000050-7	PB9160-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000050-8	PB9160-FITC	100 ug	FITC	$570		Add to Cart
BHA21000050-9	PB9160-HRP	100 ug	HRP	$570		Add to Cart
BHA21000050-10	PB9160-APC	100 ug	APC	$670		Add to Cart
BHA21000050-11	PB9160-PE	100 ug	PE	$670		Add to Cart
BHA21000050-12	PB9160-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000050-13	PB9160-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000050-2	PB9160-10ug	10 ug	Sample	$99		Add to Cart

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