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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SIRT1 Antibody Picoband®

SKU : BHA21000063

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Mfr.No.	PB9159, PB9159-10ug, PB9159-Biotin, PB9159-Cy3, PB9159-Dylight488, PB9159-Dylight550, PB9159-Dylight594, PB9159-FITC, PB9159-HRP, PB9159-APC, PB9159-PE, PB9159-iFluor647, PB9159-carrier-free
Alternative Names	NAD-dependent protein deacetylase sirtuin-1
Background	Sirtuin 1, also known as SIR2L1 or SIRT1, is a protein that in humans is encoded by the SIRT1 gene. It is mapped to 10q21.3. Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. Furthermore, Sirtuin 1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SIRT1 Antibody Picoband® catalog # PB9159. Tested in IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	NAD-dependent protein deacetylase that links transcriptional regulation ly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autop
Host	Rabbit
Immunogen Region	E.coli-derived human SIRT1 recombinant protein (Position: R112-K311). Human SIRT1 shares 90% amino acid (aa) sequence identity with mouse SIRT1.
Isotype	Rabbit IgG
Molecular Weight	120 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	NAD-dependent protein deacetylase sirtuin-1;hSIRT1;3.5.1.-;Regulatory protein SIR2 homolog 1;SIR2-like protein 1;hSIR2;SirtT1 75 kDa fragment;75SirT1;SIRT1;SIR2L1;
Tissue Specificity	Widely expressed. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q96EB6
Gene Id	23411
Gene Name	SIRT1
Sequence	Belongs to the sirtuin family. Class I subfamily.
Subcellular Location	Nucleus, PML body. Cytoplasm. Nucleus . Recruited to the nuclear bodies via its interaction with PML. Colocalized with APEX1 in the nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human

Reference	1. Wilson BJ, Tremblay AM, Deblois G, Sylvain-Drolet G, Giguère V (Jul 2010). "An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha.". Mol. Endocrinol. 24 (7): 134958. 2. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P (Mar 2005). "Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1". Nature 434 (7029): 1138. 3. Nemoto S, Fergusson MM, Finkel T (Apr 2005). "SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1 alpha". J Biol Chem. 280 (16): 1645660.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000063-1	PB9159	100 ug	-	$370		Add to Cart
BHA21000063-3	PB9159-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000063-4	PB9159-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000063-5	PB9159-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000063-6	PB9159-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000063-7	PB9159-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000063-8	PB9159-FITC	100 ug	FITC	$570		Add to Cart
BHA21000063-9	PB9159-HRP	100 ug	HRP	$570		Add to Cart
BHA21000063-10	PB9159-APC	100 ug	APC	$670		Add to Cart
BHA21000063-11	PB9159-PE	100 ug	PE	$670		Add to Cart
BHA21000063-12	PB9159-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000063-13	PB9159-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000063-2	PB9159-10ug	10 ug	Sample	$99		Add to Cart

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