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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SIAH Interacting Protein/CACYBP Antibody Picoband®

SKU : BHA21000870

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Mfr.No.	RP1104, RP1104-10ug, RP1104-Biotin, RP1104-Cy3, RP1104-Dylight488, RP1104-Dylight550, RP1104-Dylight594, RP1104-FITC, RP1104-HRP, RP1104-APC, RP1104-PE, RP1104-iFluor647, RP1104-carrier-free
Alternative Names	Calcyclin-binding protein
Background	Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene. And this gene is mapped to 1q24-q25. The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. In addition, it probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alteatively spliced transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SIAH Interacting Protein/CACYBP Antibody catalog # RP1104. Tested in Flow Cytometry, IP, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human CACYBP, different from the related mouse sequence by five amino acids, and from the related rat sequence by six amino acids.
Isotype	Rabbit IgG
Molecular Weight	26 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Calcyclin-binding protein;CacyBP;hCacyBP;S100A6-binding protein;Siah-interacting protein;CACYBP;S100A6BP, SIP;PNAS-107;
Tissue Specificity	Widely expressed.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	Q9HB71
Gene Id	27101
Gene Name	CACYBP
Subcellular Location	Nucleus . Cytoplasm . Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IP, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunocytochemistry/Immunofluorescence,2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human Immunoprecipitation, 0.5-2 ug/ml, Human

Reference	1. Matsuzawa, S., Reed, J. C. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.Molec. Cell 7: 915-926, 2001. 2. Sun S, Ning X, Liu J, et al. (2007). "Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma.". Biochem. Biophys. Res. Commun. 356 (4): 86471.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000870-1	RP1104	100 ug	-	$370		Add to Cart
BHA21000870-2	RP1104-10ug	10 ug	Sample	$99		Add to Cart
BHA21000870-3	RP1104-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000870-4	RP1104-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000870-5	RP1104-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000870-6	RP1104-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000870-7	RP1104-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000870-8	RP1104-FITC	100 ug	FITC	$570		Add to Cart
BHA21000870-9	RP1104-HRP	100 ug	HRP	$570		Add to Cart
BHA21000870-10	RP1104-APC	100 ug	APC	$670		Add to Cart
BHA21000870-11	RP1104-PE	100 ug	PE	$670		Add to Cart
BHA21000870-12	RP1104-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000870-13	RP1104-carrier-free	100 ug	carrier-free	$370		Add to Cart

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