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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SHIP/INPP5D Antibody Picoband®

SKU : BHA21001724

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Mfr.No.	A03358, A03358-10ug, A03358-Biotin, A03358-Cy3, A03358-Dylight488, A03358-Dylight550, A03358-Dylight594, A03358-FITC, A03358-HRP, A03358-APC, A03358-PE, A03358-iFluor647, A03358-carrier-free
Alternative Names	inositol polyphosphate-5-phosphatase D
Background	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 is an enzyme that in humans is encoded by the INPP5D gene. This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SHIP/INPP5D Antibody Picoband® catalog # A03358. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns (3,4,5)P3) to produce PtdIns (3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human SHIP, which shares 95.1% and 97.6% amino acid (aa) sequence identity with mouse and rat SHIP, respectively.
Isotype	Rabbit IgG
Molecular Weight	145 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1; p150Ship; hp51CN; INPP5D; SHIP; SHIP1
Tissue Specificity	Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level).
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Q92835
Gene Id	3635
Gene Name	INPP5D
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot,0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section),0.5-1ug/ml<br>

Reference	1. "Entrez Gene: INPP5D inositol polyphosphate-5-phosphatase, 145kDa".<br /><br />2. Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (May 2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cellular Signalling. 12 (5): 31726.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001724-1	A03358	100 ug	-	$370		Add to Cart
BHA21001724-2	A03358-10ug	10 ug	Sample	$99		Add to Cart
BHA21001724-3	A03358-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001724-4	A03358-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001724-5	A03358-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001724-6	A03358-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001724-7	A03358-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001724-8	A03358-FITC	100 ug	FITC	$570		Add to Cart
BHA21001724-9	A03358-HRP	100 ug	HRP	$570		Add to Cart
BHA21001724-10	A03358-APC	100 ug	APC	$670		Add to Cart
BHA21001724-11	A03358-PE	100 ug	PE	$670		Add to Cart
BHA21001724-12	A03358-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001724-13	A03358-carrier-free	100 ug	carrier-free	$370		Add to Cart

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