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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SHC/SHC1 Antibody Picoband®

SKU : BHA21000263

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Mfr.No.	PB9391, PB9391-10ug, PB9391-Biotin, PB9391-Cy3, PB9391-Dylight488, PB9391-Dylight550, PB9391-Dylight594, PB9391-FITC, PB9391-HRP, PB9391-APC, PB9391-PE, PB9391-iFluor647, PB9391-carrier-free
Alternative Names	SHC-transforming protein 1
Background	SHC, also known as SHC1 (SHC-transforming protein 1) or SHCA, is a protein that in humans is encoded by the SHC1 gene. SCOP classifies the 3D structure as belonging to the SH2 domain family. This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SHC/SHC1 Antibody Picoband® catalog # PB9391. Tested in IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosin
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human SHC, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	46 kDa, 52 kDa, 66 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	SHC-transforming protein 1;SHC-transforming protein 3;SHC-transforming protein A;Src homology 2 domain-containing-transforming protein C1;SH2 domain protein C1;SHC1;SHC, SHCA;
Tissue Specificity	Widely expressed. Expressed in neural stem cells but absent in mature neurons.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P29353
Gene Id	6464
Gene Name	SHC1
Sequence	Contains 1 PID domain.
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, IHC-F, WB
Description	Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human, - Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. Harun, R. B., Smith, K. K., Leek, J. P., Markham, A. F., Norris, A., Morrison, J. F. J.Characterization of human SHC p66 cDNA and its processed pseudogene mapping to Xq12-q13.1.Genomics 42: 349-352, 1997. 2. Huebner, K., Kastury, K., Druck, T., Salcini, A. E., Lanfrancone, L., Pelicci, G., Lowenstein, E., Li, W., Park, S.-H., Cannizzaro, L., Pelicci, P. G., Schlessinger, J.Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).Genomics 22: 281-287, 1994. 3. Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Foi, G., Nicoletti, I., Grignani, F., Pawson, T., Pelicci, P. G.A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.Cell 70: 93-104, 1992.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000263-1	PB9391	100 ug	-	$370		Add to Cart
BHA21000263-2	PB9391-10ug	10 ug	Sample	$99		Add to Cart
BHA21000263-3	PB9391-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000263-4	PB9391-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000263-5	PB9391-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000263-6	PB9391-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000263-7	PB9391-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000263-8	PB9391-FITC	100 ug	FITC	$570		Add to Cart
BHA21000263-9	PB9391-HRP	100 ug	HRP	$570		Add to Cart
BHA21000263-10	PB9391-APC	100 ug	APC	$670		Add to Cart
BHA21000263-11	PB9391-PE	100 ug	PE	$670		Add to Cart
BHA21000263-12	PB9391-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000263-13	PB9391-carrier-free	100 ug	carrier-free	$370		Add to Cart

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