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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SFTPA1/2 Antibody Picoband®

SKU : BHA21000295

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Mfr.No.	PB9390, PB9390-10ug, PB9390-Biotin, PB9390-Cy3, PB9390-Dylight488, PB9390-Dylight550, PB9390-Dylight594, PB9390-FITC, PB9390-HRP, PB9390-APC, PB9390-PE, PB9390-iFluor647, PB9390-carrier-free
Alternative Names	Pulmonary surfactant-associated protein A2
Background	SFTPA1/2 is also known as SP-A. SFTPA1 encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alteate splicing results in multiple transcript variants. SFTPA2 is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SFTPA1/2 Antibody Picoband® catalog # PB9390. Tested in IF, IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of humanSFTPA1/2, different from the related mouse sequence by four amino acids, and from the related rat sequence by five amino acids.
Isotype	Rabbit IgG
Molecular Weight	26 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Pulmonary surfactant-associated protein A2;PSP-A;PSPA;SP-A;SP-A2;35 kDa pulmonary surfactant-associated protein;Alveolar proteinosis protein;Collectin-5;SFTPA2;COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B;
Tissue Specificity	Expressed in B-cell lines and T-lymphocytes. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q8IWL1
Gene Id	653509/729238
Gene Name	SFTPA2
Sequence	Belongs to the SFTPA family.
Subcellular Location	Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, IHC-F, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Mouse, Rat, - Immunofluorescence, 5 ug/ml, Rat

Reference	1. Perez-Gil J, Weaver TE (June 2010). "Pulmonary surfactant pathophysiology: current models and open questions".Physiology (Bethesda) 25 (3): 13241. 2. Phelps DS (2001). "Surfactant regulation of host defense function in the lung: a question of balance". Pediatr Pathol Mol Med 20 (4): 26992.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000295-1	PB9390	100 ug	-	$370		Add to Cart
BHA21000295-2	PB9390-10ug	10 ug	Sample	$99		Add to Cart
BHA21000295-3	PB9390-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000295-4	PB9390-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000295-5	PB9390-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000295-6	PB9390-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000295-7	PB9390-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000295-8	PB9390-FITC	100 ug	FITC	$570		Add to Cart
BHA21000295-9	PB9390-HRP	100 ug	HRP	$570		Add to Cart
BHA21000295-10	PB9390-APC	100 ug	APC	$670		Add to Cart
BHA21000295-11	PB9390-PE	100 ug	PE	$670		Add to Cart
BHA21000295-12	PB9390-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000295-13	PB9390-carrier-free	100 ug	carrier-free	$370		Add to Cart

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