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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Serine-protein kinase ATM ATM Antibody Picoband®

SKU : BHA21000066

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Mfr.No.	RP1040, RP1040-10ug, RP1040-Biotin, RP1040-Cy3, RP1040-Dylight488, RP1040-Dylight550, RP1040-Dylight594, RP1040-FITC, RP1040-HRP, RP1040-APC, RP1040-PE, RP1040-iFluor647, RP1040-carrier-free
Alternative Names	Serine-protein kinase ATM
Background	ATM (ataxia telangiectasia mutated), also known as TEL1 or TELO1, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. The ATM protein is a member of the phosphatidylinositol 3-kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. The ATM gene is mapped to chromosome 11q22.3. ATM has an essential role in the reconstitutive capacity of hematopoietic stem cells but is not as important for the proliferation or differentiation of progenitors in a telomere-independent manner. ATM functions ly in the repair of chromosomal DNA double-stranded breaks by maintaining DNA ends in repair complexes generated during lymphocyte gene assembly.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Serine-protein kinase ATM ATM Antibody catalog # RP1040. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus s
Host	Rabbit
Immunogen Region	E.coli-derived human ATM recombinant protein (Position: D2870-V3056). Human ATM shares 95% amino acid (aa) sequence identity with mouse ATM.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Serine-protein kinase ATM;2.7.11.1;Ataxia telangiectasia mutated;A-T mutated;ATM;
Tissue Specificity	Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.

Uniprot	Q13315
Gene Id	472
Gene Name	ATM
Sequence	Belongs to the PI3/PI4-kinase family. ATM subfamily.
Subcellular Location	Nucleus. Cytoplasmic vesicle. Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Allen, D. M., van Praag, H., Ray, J., Weaver, Z., Winrow, C. J., Carter, T. A., Braquet, R., Harrington, E., Ried, T., Brown, K. D., Gage, F. H., Barlow, C. Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev. 15: 554-566, 2001. 2. Bakkenist, C. J., Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.Nature 421: 499-506, 2003. 3. Chong, M. J., Murray, M. R., Gosink, E. C., Russell, H. R. C., Srinivasan, A., Kapsetaki, M., Korsmeyer, S. J., McKinnon, P. J. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc. Nat. Acad. Sci. 97: 889-894, 2000.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000066-1	RP1040	100 ug	-	$370		Add to Cart
BHA21000066-3	RP1040-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000066-4	RP1040-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000066-5	RP1040-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000066-6	RP1040-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000066-7	RP1040-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000066-8	RP1040-FITC	100 ug	FITC	$570		Add to Cart
BHA21000066-9	RP1040-HRP	100 ug	HRP	$570		Add to Cart
BHA21000066-10	RP1040-APC	100 ug	APC	$670		Add to Cart
BHA21000066-11	RP1040-PE	100 ug	PE	$670		Add to Cart
BHA21000066-12	RP1040-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000066-13	RP1040-carrier-free	100 ug	carrier-free	$370		Add to Cart
BHA21000066-2	RP1040-10ug	10 ug	Sample	$99		Add to Cart

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