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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SERCA1 ATPase/ATP2A1 Antibody Picoband®

SKU : BHA21000170

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Mfr.No.	RP1053, RP1053-10ug, RP1053-Biotin, RP1053-Cy3, RP1053-Dylight488, RP1053-Dylight550, RP1053-Dylight594, RP1053-FITC, RP1053-HRP, RP1053-APC, RP1053-PE, RP1053-iFluor647, RP1053-carrier-free
Alternative Names	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Background	SERCA1, also called ATP2A1, is an enzyme that in humans is encoded by the ATP2A1 gene. This gene encodes one of the SERCA Ca (2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. The SERCA1 gene is mapped to 16p11.2. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. It has been determined that the human SERCA1 gene is 26 kb long and contains 23 exons, of which can be alteatively spliced. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SERCA1 ATPase/ATP2A1 Antibody catalog # RP1053. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key regulator of striated muscle performance by acting as the major Ca (2+) ATPase responsible for the reuptake of cytosolic Ca (2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytoso
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human SERCA1 ATPase, different from the related mouse and rat sequences by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	110 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1;SERCA1;SR Ca (2+)-ATPase 1;3.6.3.8;Calcium pump 1;Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform;Endoplasmic reticulum class 1/2 Ca (2+) ATPase;ATP2A1;
Tissue Specificity	Skeletal muscle, fast twitch muscle (type II) fibers.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O14983
Gene Id	487
Gene Name	ATP2A1
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, Human, By Heat Weste blot, 0.1-0.5ug/ml, Mouse, Rat, Human

Reference	1. Brandl, C. J., Green, N. M., Korczak, B., MacLennan, D. H. Two Ca(2+) ATPase genes: homologies and mechanistic implications of deduced amino acid sequences. Cell 44: 597-607, 1986. 2. Karpati, G., Charuk, J., Carpenter, S., Jablecki, C., Holland, P. Myopathy caused by a deficiency of Ca(2+)-adenosine triphosphatase in sarcoplasmic reticulum (Brody's disease). Ann. Neurol. 20: 38-49, 1986. 3. Zhang, Y., Fujii, J., Phillips, M. S., Chen, H.-S., Karpati, G., Yee, W.-C., Schrank, B., Coblath, D. R., Boyland, K. B., MacLennan, D. H. Characterization of cDNA and genomic DNA encoding SERCA1, the Ca(2+)-ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum, and its elimination as a candidate gene for Brody disease. Gemomics 30: 415-424, 1995.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000170-1	RP1053	100 ug	-	$370		Add to Cart
BHA21000170-2	RP1053-10ug	10 ug	Sample	$99		Add to Cart
BHA21000170-3	RP1053-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000170-4	RP1053-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000170-5	RP1053-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000170-6	RP1053-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000170-7	RP1053-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000170-8	RP1053-FITC	100 ug	FITC	$570		Add to Cart
BHA21000170-9	RP1053-HRP	100 ug	HRP	$570		Add to Cart
BHA21000170-10	RP1053-APC	100 ug	APC	$670		Add to Cart
BHA21000170-11	RP1053-PE	100 ug	PE	$670		Add to Cart
BHA21000170-12	RP1053-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000170-13	RP1053-carrier-free	100 ug	carrier-free	$370		Add to Cart

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