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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SEMA4A Antibody Picoband®

SKU : BHA21005387

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Mfr.No.	A06779-3, A06779-3-10ug, A06779-3-Biotin, A06779-3-Cy3, A06779-3-Dylight488, A06779-3-Dylight550, A06779-3-Dylight594, A06779-3-FITC, A06779-3-HRP, A06779-3-APC, A06779-3-PE, A06779-3-iFluor647, A06779-3-carrier-free
Alternative Names	PR/SET domain 5
Background	Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene. This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alteatively spliced transcript variants encoding different isoforms have been identified.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SEMA4A Antibody Picoband® catalog # A06779-3. Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (
Host	Rabbit
Immunogen Region	E.coli-derived human SEMA4A recombinant protein (Position: R81-N754).
Isotype	Rabbit IgG
Molecular Weight	105 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	PR domain zinc finger protein 5; PR domain-containing protein 5; PRDM5; PFM2
Tissue Specificity	Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9H3S1
Gene Id	64218
Gene Name	SEMA4A
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Abid, A., Ismail, M., Mehdi, S. Q., Khaliq, S. Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases. (Letter) J. Med. Genet. 43: 378-381, 2006. <br /><br />2. Bryant, L., Lozynska, O., Han, G., Morgan, J. I. W., Gai, X., Maguire, A. M., Aleman, T., Bennett, J. On variants and disease-causing mutations: Case studies of a SEMA4A variant identified in inherited blindness. Ophthalmic Genet. 39: 144-146, 2018. <br /><br />3. Delgoffe, G. M., Woo, S.-R., Tuis, M. E., Gravano, D. M., Guy, C., Overacre, A. E., Bettini, M. L., Vogel, P., Finkelstein, D., Bonnevier, J., Workman, C. J., Vignali, D. A. A. Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature 501: 252-256, 2013.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005387-1	A06779-3	-	100 ug	$370		Add to Cart
BHA21005387-2	A06779-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21005387-3	A06779-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005387-4	A06779-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005387-5	A06779-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005387-6	A06779-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005387-7	A06779-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005387-8	A06779-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21005387-9	A06779-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21005387-10	A06779-3-APC	APC	100 ug	$670		Add to Cart
BHA21005387-11	A06779-3-PE	PE	100 ug	$670		Add to Cart
BHA21005387-12	A06779-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005387-13	A06779-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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