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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SELENOT Antibody Picoband®

SKU : BHA21004765

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Mfr.No.	A31970, A31970-10ug, A31970-Biotin, A31970-Cy3, A31970-Dylight488, A31970-Dylight550, A31970-Dylight594, A31970-FITC, A31970-HRP, A31970-APC, A31970-PE, A31970-iFluor647, A31970-carrier-free
Alternative Names	retrotransposon Gag like 10
Background	This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SELENOT Antibody Picoband® catalog # A31970. Tested in ELISA, Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Could induce apoptosis in a BH3 domain-dependent manner. The interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.
Host	Rabbit
Immunogen Region	E.coli-derived human SELENOT recombinant protein (Position: S20-S195).
Isotype	Rabbit IgG
Molecular Weight	22 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Protein Bop; BH3-only protein; Retrotransposon Gag-like protein 10; RTL10; BOP, C22orf29
Tissue Specificity	Ubiquitously expressed.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P62341
Gene Id	51714
Gene Name	SELENOT
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, IF, IHC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse, Rat Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Dikiy, A., Novoselov, S. V., Fomenko, D. E., Sengupta, A., Carlson, B. A., Cey, R. L., Ginalski, K., Grishin, N. V., Hatfield, D. L., Gladyshev, V. N. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry 46: 6871-6882, 2007. 2. Kryukov, G. V., Castellano, S., Novoselov, S. V., Lobanov, A. V., Zehtab, O., Guigo, R., Gladyshev, V. N. Characterization of mammalian selenoproteomes. Science 300: 1439-1443, 2003. 3. Kryukov, G. V., Kryukov, V. M., Gladyshev, V. N. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. J. Biol. Chem. 274: 33888-33897, 1999.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004765-1	A31970	-	100 ug	$370		Add to Cart
BHA21004765-2	A31970-10ug	Sample	10 ug	$99		Add to Cart
BHA21004765-3	A31970-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004765-4	A31970-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004765-5	A31970-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004765-6	A31970-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004765-7	A31970-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004765-8	A31970-FITC	FITC	100 ug	$570		Add to Cart
BHA21004765-9	A31970-HRP	HRP	100 ug	$570		Add to Cart
BHA21004765-10	A31970-APC	APC	100 ug	$670		Add to Cart
BHA21004765-11	A31970-PE	PE	100 ug	$670		Add to Cart
BHA21004765-12	A31970-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004765-13	A31970-carrier-free	carrier-free	100 ug	$370		Add to Cart

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