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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SDHB Antibody Picoband®

SKU : BHA21007004

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Mfr.No.	PA1718, PA1718-10ug, PA1718-Biotin, PA1718-Cy3, PA1718-Dylight488, PA1718-Dylight550, PA1718-Dylight594, PA1718-FITC, PA1718-HRP, PA1718-APC, PA1718-PE, PA1718-iFluor647, PA1718-carrier-free
Alternative Names	Succinate dehydrogenase (ubiquinone) iron-sulfur subunit, mitochondrial
Background	SDHB (Succinate Dehydrogenase Complex, Subunit B, iron sulfur protein), also known as iron-sulfur subunit of complex II (Ip) or SDH2, HOMOLOG OF, is a protein that in humans is encoded by the SDHB gene. SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex. The SDHB gene is mapped on 1p36.13. The entire SDHB transcript is encoded by 8 exons within approximately 40 kb by Au et al (1995). Pollard et al. (2005) stated that the nuclear-encoded Krebs cycle enzymes fumarate hydratase and succinate dehydrogenases like SDHB act as tumor suppressors, and germline mutations in these genes predispose individuals to leiomyomas and renal cancer and to paragangliomas, respectively. In affected members of families with paragangliomas-4, mutations were identified in the SDHB gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SDHB Antibody catalog # PA1718. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human SDHB, different from the related rat sequence by one amino acid and mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	29 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Succinate dehydrogenase (ubiquinone) iron-sulfur subunit, mitochondrial;1.3.5.1;Iron-sulfur subunit of complex II;Ip;SDHB;SDH, SDH1;
Tissue Specificity	Wide tissue distribution. Undetectable in placental tissue.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P21912
Gene Name	SDHB
Sequence	Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
Subcellular Location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat<br>

Reference	1. Au, H. C., Ream-Robinson, D., Bellew, L. A., Broomfield, P. L. E., Saghbini, M., Scheffler, I. E. Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase. Gene 159: 249-253, 1995. <br /><br />2. Brouwers, F. M., Eisenhofer, G., Tao, J. J., Kant, J. A., Adams, K. T., Linehan, W. M., Pacak, K. High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing. J. Clin. Endocr. Metab. 91: 4505-4509, 2006.<br /><br />3. Pollard, P. J., Briere, J. J., Alam, N. A., Barwell, J., Barclay, E., Wortham, N. C., Hunt, T., Mitchell, M., Olpin, S., Moat, S. J., Hargreaves, I. P., Heales, S. J., and 9 others.Accumulation of Krebs cycle intermediates and over-expression of HIF1-alpha in tumours which result from germline FH and SDH mutations. Hum. Molec. Genet. 14: 2231-2239, 2005.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007004-1	PA1718	-	100 ug	$370		Add to Cart
BHA21007004-2	PA1718-10ug	Sample	10 ug	$99		Add to Cart
BHA21007004-3	PA1718-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007004-4	PA1718-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007004-5	PA1718-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007004-6	PA1718-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007004-7	PA1718-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007004-8	PA1718-FITC	FITC	100 ug	$570		Add to Cart
BHA21007004-9	PA1718-HRP	HRP	100 ug	$570		Add to Cart
BHA21007004-10	PA1718-APC	APC	100 ug	$670		Add to Cart
BHA21007004-11	PA1718-PE	PE	100 ug	$670		Add to Cart
BHA21007004-12	PA1718-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007004-13	PA1718-carrier-free	carrier-free	100 ug	$370		Add to Cart

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