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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SCF/KITLG Antibody Picoband®

SKU : BHA21006893

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Mfr.No.	PA1565, PA1565-10ug, PA1565-Biotin, PA1565-Cy3, PA1565-Dylight488, PA1565-Dylight550, PA1565-Dylight594, PA1565-FITC, PA1565-HRP, PA1565-APC, PA1565-PE, PA1565-iFluor647, PA1565-carrier-free
Alternative Names	Kit ligand
Background	Stem Cell Factor (also known as SCF, kit-ligand, KL, or steel factor) is a cytokine that binds to the c-Kit receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. SCF is localized to the long arm of human chromosome 12, between 12q14.3 and 12qter. SCF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. SCF has been shown to increase the survival of HSCs in vitro and contributes to the self renewal and maintenance of HSCs in-vivo. HSCs at all stages of development express the same levels of the receptor for SCF (c-Kit). The stromal cells that surround HSCs are a component of the stem cell niche, and they release a number of ligands, including SCF.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SCF/KITLG Antibody catalog # PA1565. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesi
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human SCF.
Isotype	Rabbit IgG
Molecular Weight	18.4 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Kit ligand;Mast cell growth factor;MGF;Stem cell factor;SCF;c-Kit ligand;Soluble KIT ligand;sKITLG;KITLG;MGF, SCF;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P21583
Gene Name	KITLG
Sequence	Belongs to the SCF family.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Geissler, E. N., Liao, M., Brook, J. D., Martin, F. H., Zsebo, K. M., Housman, D. E., Galli, S. J. Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter. Somat. Cell Molec. Genet. 17: 207-214, 1991.<br /><br />2. Kent D, Copley M, Benz C, Dykstra B, Bowie M, Eaves C (April 2008). "Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathway". Clin. Cancer Res. 14 (7): 192630.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006893-1	PA1565	-	100 ug	$370		Add to Cart
BHA21006893-2	PA1565-10ug	Sample	10 ug	$99		Add to Cart
BHA21006893-3	PA1565-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006893-4	PA1565-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006893-5	PA1565-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006893-6	PA1565-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006893-7	PA1565-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006893-8	PA1565-FITC	FITC	100 ug	$570		Add to Cart
BHA21006893-9	PA1565-HRP	HRP	100 ug	$570		Add to Cart
BHA21006893-10	PA1565-APC	APC	100 ug	$670		Add to Cart
BHA21006893-11	PA1565-PE	PE	100 ug	$670		Add to Cart
BHA21006893-12	PA1565-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006893-13	PA1565-carrier-free	carrier-free	100 ug	$370		Add to Cart

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