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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SCF/KITLG Antibody Picoband®

SKU : BHA21006585

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Mfr.No.	RP1010, RP1010-10ug, RP1010-Biotin, RP1010-Cy3, RP1010-Dylight488, RP1010-Dylight550, RP1010-Dylight594, RP1010-FITC, RP1010-HRP, RP1010-APC, RP1010-PE, RP1010-iFluor647, RP1010-carrier-free
Alternative Names	Kit ligand
Background	Stem Cell Factor (also known as SCF, kit-ligand, KL, or steel factor) is a cytokine that binds to the c-Kit receptor (CD117). The SCF gene is mapped to 12q21.32. SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis. SCF may be used along with other cytokines to culture HSCs and hematopoietic progenitors. The expansion of these cells ex-vivo (outside the body) would allow advances in bone-marrow transplantation, in which HSCs are transferred to a patient to re-establish blood formation. One of the problems of injecting SCF for therapeutic purposes is that SCF activates mast cells. The injection of SCF has been shown to cause allergic-like symptoms and the proliferation of mast cells and melanocytes.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-SCF/KITLG Antibody catalog # RP1010. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesi
Host	Rabbit
Immunogen Region	E. coli-derived human SCF recombinant protein (Position: E26-A190).
Isotype	Rabbit IgG
Molecular Weight	18 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Kit ligand;Mast cell growth factor;MGF;Stem cell factor;SCF;c-Kit ligand;Soluble KIT ligand;sKITLG;KITLG;MGF, SCF;
Note	Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. Carrier free (No BSA) form available in stock. If you want this antibody carrier free please specify "Carrier Free" or "No BSA" in your order note.

Uniprot	P21583
Gene Name	KITLG
Sequence	Belongs to the SCF family.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, -<br>ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Geissler, E. N., Liao, M., Brook, J. D., Martin, F. H., Zsebo, K. M., Housman, D. E., Galli, S. J.Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter.Somat. Cell Molec. Genet. 17: 207-214, 1991.<br /><br />2. Heissig, B., Hattori, K., Dias, S., Friedrich, M., Ferris, B., Hackett, N. R., Crystal, R. G., Besmer, P., Lyden, D., Moore, M. A. S., Werb, Z., Rafii, S.Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of Kit-ligand.Cell 109: 625-637, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006585-1	RP1010	-	100 ug	$370		Add to Cart
BHA21006585-2	RP1010-10ug	Sample	10 ug	$99		Add to Cart
BHA21006585-3	RP1010-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006585-4	RP1010-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006585-5	RP1010-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006585-6	RP1010-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006585-7	RP1010-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006585-8	RP1010-FITC	FITC	100 ug	$570		Add to Cart
BHA21006585-9	RP1010-HRP	HRP	100 ug	$570		Add to Cart
BHA21006585-10	RP1010-APC	APC	100 ug	$670		Add to Cart
BHA21006585-11	RP1010-PE	PE	100 ug	$670		Add to Cart
BHA21006585-12	RP1010-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006585-13	RP1010-carrier-free	carrier-free	100 ug	$370		Add to Cart

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