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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SARS-CoV-2 ORF3a Antibody

SKU : BHA21003167

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Mfr.No.	A33994, A33994-10ug, A33994-Biotin, A33994-Cy3, A33994-Dylight488, A33994-Dylight550, A33994-Dylight594, A33994-FITC, A33994-HRP, A33994-APC, A33994-PE, A33994-iFluor647, A33994-carrier-free
Alternative Names	ORF3a protein
Background	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF3a encodes a viral accessory protein. Based on its similarity to other coronavirus proteins, ORF3a protein is thought to be a protein with ion channel activity (viroporin) that activates the NLRP3 inflammasome. ORF3a may also play a role in virus replication and pathogenesis.
Clonality	Polyclonal
Description	Boster Bio Anti-SARS-CoV-2 ORF3a Antibody catalog # A33994. Tested in ELISA applications. This antibody reacts with Human.
Function	Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Host	Rabbit
Immunogen Region	MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASggggFQSASKIITLKKRWQLALSKGVHFVCNLggggQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL
Isotype	Rabbit IgG
Molecular Weight	140 kDa, 130 kDa, 110 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	ORF3a protein; ORF3a; Accessory protein 3a; Protein 3a; Protein U274; Protein X1
Tissue Specificity	Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. .
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P0DTC3
Gene Id	43740569
Gene Name	3a
Subcellular Location	Cytoplasm .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA
Description	ELISA, 0.001-0.1ug/ml, Human

Reference	1. Gordon DE, et al. Nature, 2020 Jul.<br /><br />2. Gordon DE, et al. Science, 2020 Oct 15. <br /><br />3. Hassan SS, et al. Genomics, 2020 Sep.<br /><br />4. Wu F, et al. Nature, 2020 Mar.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003167-1	A33994	-	100 ug	$415		Add to Cart
BHA21003167-2	A33994-10ug	Sample	10 ug	$99		Add to Cart
BHA21003167-3	A33994-Biotin	Biotin	100 ug	$615		Add to Cart
BHA21003167-4	A33994-Cy3	Cy3	100 ug	$615		Add to Cart
BHA21003167-5	A33994-Dylight488	Dylight488	100 ug	$615		Add to Cart
BHA21003167-6	A33994-Dylight550	Dylight550	100 ug	$615		Add to Cart
BHA21003167-7	A33994-Dylight594	Dylight594	100 ug	$615		Add to Cart
BHA21003167-8	A33994-FITC	FITC	100 ug	$615		Add to Cart
BHA21003167-9	A33994-HRP	HRP	100 ug	$615		Add to Cart
BHA21003167-10	A33994-APC	APC	100 ug	$715		Add to Cart
BHA21003167-11	A33994-PE	PE	100 ug	$715		Add to Cart
BHA21003167-12	A33994-iFluor647	iFluor647	100 ug	$715		Add to Cart
BHA21003167-13	A33994-carrier-free	carrier-free	100 ug	$415		Add to Cart

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