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Home / Primary Antibodies / Polyclonal Antibodies

Anti-S100 beta/S100B Antibody Picoband®

SKU : BHA21006703

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Mfr.No.	PA1303, PA1303-10ug, PA1303-Biotin, PA1303-Cy3, PA1303-Dylight488, PA1303-Dylight550, PA1303-Dylight594, PA1303-FITC, PA1303-HRP, PA1303-APC, PA1303-PE, PA1303-iFluor647, PA1303-carrier-free
Alternative Names	Protein S100-B
Background	S100 calcium binding protein B or S100B is a protein of the S-100 protein family. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. S100B is a glial-derived protein that is a well-established biomarker for severity of neurological injury and prognosis for recovery. S100 beta is a calcium-binding protein that is expressed at high levels in brain primarily by astrocytes. Addition of the disulfide-bonded dimeric form of S100 beta to primary neuronal and glial cultures and established cell lines induces axonal extension and alterations in astrocyte proliferation and phenotype, but evidence that S100 beta exerts the same effects in vivo has not been presented. Reeves et al. (1994) demonstrated that the same effects of the S100B protein are exerted in vivo. They found that both astrocytosis and neurite proliferation occurred in transgenic mice expressing elevated levels of S100b. They suggested that these transgenic mice represent a useful model for studies of the role of S100B in glial-neuronal interactions in normal development and function of the brain and for analyzing the significance of elevated levels of the protein in Down syndrome and Alzheimer disease.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-S100 beta/S100B Antibody catalog # PA1303. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting hig
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human S100 beta, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	11 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Protein S100-B;S-100 protein beta chain;S-100 protein subunit beta;S100 calcium-binding protein B;S100B;
Tissue Specificity	Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P04271
Gene Name	S100B
Sequence	Belongs to the S-100 family.
Subcellular Location	Cytoplasm . Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Wainwright, M. S.; Craft, J. M.; Griffin, W. S. T.; Marks, A.; Pineda, J.; Padgett, K. R.; Van Eldik, L. J. : Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia. Ann. Neurol. 56: 61-67, 2004.<br /><br />2. Reeves, R. H.; Yao, J.; Crowley, M. R.; Buck, S.; Zhang, X.; Yarowsky, P.; Gearhart, J. D.; Hilt, D. C. : Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice. Proc. Nat. Acad. Sci. 91: 5359-5363, 1994.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006703-1	PA1303	-	100 ug	$370		Add to Cart
BHA21006703-2	PA1303-10ug	Sample	10 ug	$99		Add to Cart
BHA21006703-3	PA1303-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006703-4	PA1303-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006703-5	PA1303-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006703-6	PA1303-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006703-7	PA1303-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006703-8	PA1303-FITC	FITC	100 ug	$570		Add to Cart
BHA21006703-9	PA1303-HRP	HRP	100 ug	$570		Add to Cart
BHA21006703-10	PA1303-APC	APC	100 ug	$670		Add to Cart
BHA21006703-11	PA1303-PE	PE	100 ug	$670		Add to Cart
BHA21006703-12	PA1303-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006703-13	PA1303-carrier-free	carrier-free	100 ug	$370		Add to Cart

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