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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RPA70/RPA1 Antibody Picoband®

SKU : BHA21000787

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Mfr.No.	PB9886, PB9886-10ug, PB9886-Biotin, PB9886-Cy3, PB9886-Dylight488, PB9886-Dylight550, PB9886-Dylight594, PB9886-FITC, PB9886-HRP, PB9886-APC, PB9886-PE, PB9886-iFluor647, PB9886-carrier-free
Alternative Names	Replication protein A 70 kDa DNA-binding subunit
Background	Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene. This gene is mapped to chromosome 17p13.3. Replication protein A (RPA) is a heterotrimeric single-strand DNA (ssDNA)-binding protein essential for DNA replication, repair, and recombination. It is composed of 70-kD (RPA1), 32-kD (RPA2), and 14-kD (RPA3) subunits. The RPA1 subunit is responsible for high-affinity ssDNA binding. The RPA complex was originally isolated as a factor essential for in vitro replication of the papovavirus SV40. It had been found that recombinant human RPA1, purified from bacteria, exhibited ssDNA-binding activity comparable to that of the complete RPA complex. RPA1 could substitute for the complete complex in stimulating the activity of DNA polymerase alpha-primase, but it could not substitute for the complete complex in SV40 DNA replication in vitro, suggesting an important functional role for the other subunits.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-RPA70/RPA1 Antibody Picoband® catalog # PB9886. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates diff
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human RPA70, different from the related mouse sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Replication protein A 70 kDa DNA-binding subunit;RP-A p70;Replication factor A protein 1;RF-A protein 1;Single-stranded DNA-binding protein;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed;RPA1;REPA1, RPA70;
Tissue Specificity	Widely expressed; high expression found in skeletal muscle. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P27694
Gene Id	6117
Gene Name	RPA1
Subcellular Location	Nucleus . Nucleus, PML body . Enriched in PML bodies in cells displaying alteative lengthening of their telomeres. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human

Reference	1. Erdile, L. F., Heyer, W.-D., Kolodner, R., Kelly, T. J. Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication. J. Biol. Chem. 266: 12090-12098, 1991. Note: Erratum: J. Biol. Chem. 268: 2268 only, 1993. 2. Haring, S. J., Mason, A. C., Binz, S. K., Wold, M. S. Cellular functions of human RPA1: multiple roles of domains in replication, repair, and checkpoints. J. Biol. Chem. 283: 19095-19111, 2008.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000787-1	PB9886	100 ug	-	$370		Add to Cart
BHA21000787-2	PB9886-10ug	10 ug	Sample	$99		Add to Cart
BHA21000787-3	PB9886-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000787-4	PB9886-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000787-5	PB9886-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000787-6	PB9886-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000787-7	PB9886-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000787-8	PB9886-FITC	100 ug	FITC	$570		Add to Cart
BHA21000787-9	PB9886-HRP	100 ug	HRP	$570		Add to Cart
BHA21000787-10	PB9886-APC	100 ug	APC	$670		Add to Cart
BHA21000787-11	PB9886-PE	100 ug	PE	$670		Add to Cart
BHA21000787-12	PB9886-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000787-13	PB9886-carrier-free	100 ug	carrier-free	$370		Add to Cart

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