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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RNF8 Antibody Picoband®

SKU : BHA21003727

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Mfr.No.	A00707-2, A00707-2-10ug, A00707-2-Biotin, A00707-2-Cy3, A00707-2-Dylight488, A00707-2-Dylight550, A00707-2-Dylight594, A00707-2-FITC, A00707-2-HRP, A00707-2-APC, A00707-2-PE, A00707-2-iFluor647, A00707-2-carrier-free
Alternative Names	neurotrophic tyrosine kinase, receptor, type 1
Background	E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene. The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-RNF8 Antibody Picoband® catalog # A00707-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF whic
Host	Rabbit
Immunogen Region	E.coli-derived human RNF8 recombinant protein (Position: R61-F485).
Isotype	Rabbit IgG
Molecular Weight	56 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	High affinity nerve growth factor receptor
Tissue Specificity	Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	O76064
Gene Id	9025
Gene Name	RNF8
Subcellular Location	Cell membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Bekker-Jensen, S., Rendtlew Danielsen, J., Fugger, K., Gromova, I., Nerstedt, A., Lukas, C., Bartek, J., Lukas, J., Mailand, N. HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nature Cell Biol. 12: 80-86, 2010. Note: Erratum Nature Cell Biol. 12: 412 only, 2010. 2. Ishikawa, K., Nagase, T., Suyama, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 169-176, 1998. 3. Kolas, N. K., Chapman, J. R., Nakada, S., Ylanko, J., Chahwan, R., Sweeney, F. D., Panier, S., Mendez, M., Wildenhain, J., Thomson, T. M., Pelletier, L., Jackson, S. P., Durocher, D. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science 318: 1637-1640, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003727-1	A00707-2	-	100 ug	$370		Add to Cart
BHA21003727-2	A00707-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003727-3	A00707-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003727-4	A00707-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003727-5	A00707-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003727-6	A00707-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003727-7	A00707-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003727-8	A00707-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003727-9	A00707-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003727-10	A00707-2-APC	APC	100 ug	$670		Add to Cart
BHA21003727-11	A00707-2-PE	PE	100 ug	$670		Add to Cart
BHA21003727-12	A00707-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003727-13	A00707-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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