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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RAG2 Antibody Picoband®

SKU : BHA21000694

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Mfr.No.	PB9793, PB9793-10ug, PB9793-Biotin, PB9793-Cy3, PB9793-Dylight488, PB9793-Dylight550, PB9793-Dylight594, PB9793-FITC, PB9793-HRP, PB9793-APC, PB9793-PE, PB9793-iFluor647, PB9793-carrier-free
Alternative Names	V(D)J recombination-activating protein 2
Background	Recombination activating gene 2, also known as RAG-2, is a protein that in humans is encoded by the RAG2 gene. This gene encodes a protein that is involved in the initiation of V (D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-RAG2 Antibody Picoband® catalog # PB9793. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V (D)J recombination. V (D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human RAG2, different from the related mouse sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	59 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	V (D)J recombination-activating protein 2;RAG-2;RAG2;
Tissue Specificity	Cells of the B- and T-lymphocyte lineages.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P55895
Gene Id	5897
Gene Name	RAG2
Subcellular Location	Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. "Entrez Gene: Recombination activating gene 2". 2. Callebaut, I., Moon, J.-P. The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis. Cell. Molec. Life Sci. 54: 880-891, 1998.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000694-1	PB9793	100 ug	-	$370		Add to Cart
BHA21000694-2	PB9793-10ug	10 ug	Sample	$99		Add to Cart
BHA21000694-3	PB9793-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000694-4	PB9793-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000694-5	PB9793-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000694-6	PB9793-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000694-7	PB9793-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000694-8	PB9793-FITC	100 ug	FITC	$570		Add to Cart
BHA21000694-9	PB9793-HRP	100 ug	HRP	$570		Add to Cart
BHA21000694-10	PB9793-APC	100 ug	APC	$670		Add to Cart
BHA21000694-11	PB9793-PE	100 ug	PE	$670		Add to Cart
BHA21000694-12	PB9793-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000694-13	PB9793-carrier-free	100 ug	carrier-free	$370		Add to Cart

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