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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RAG2 Antibody Picoband®

SKU : BHA21005073

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Mfr.No.	A00352, A00352-10ug, A00352-Biotin, A00352-Cy3, A00352-Dylight488, A00352-Dylight550, A00352-Dylight594, A00352-FITC, A00352-HRP, A00352-APC, A00352-PE, A00352-iFluor647, A00352-carrier-free
Alternative Names	Leptin receptor
Background	Recombination activating gene 2, also known as RAG-2, is a protein that in humans is encoded by the RAG2 gene. This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-RAG2 Antibody Picoband® catalog # A00352. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also medi
Host	Rabbit
Immunogen Region	E.coli-derived human RAG2 recombinant protein (Position: F46-K503).
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Human, Mouse
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Leptin receptor;LEP-R;HuB219;OB receptor;OB-R;CD295;LEPR;DB, OBR;
Tissue Specificity	Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P55895
Gene Id	5897
Gene Name	RAG2
Subcellular Location	Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. "Entrez Gene: Recombination activating gene 2".<br /><br />2. Callebaut, I., Moon, J.-P. The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis. Cell. Molec. Life Sci. 54: 880-891, 1998.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005073-1	A00352	-	100 ug	$370		Add to Cart
BHA21005073-2	A00352-10ug	Sample	10 ug	$99		Add to Cart
BHA21005073-3	A00352-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005073-4	A00352-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005073-5	A00352-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005073-6	A00352-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005073-7	A00352-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005073-8	A00352-FITC	FITC	100 ug	$570		Add to Cart
BHA21005073-9	A00352-HRP	HRP	100 ug	$570		Add to Cart
BHA21005073-10	A00352-APC	APC	100 ug	$670		Add to Cart
BHA21005073-11	A00352-PE	PE	100 ug	$670		Add to Cart
BHA21005073-12	A00352-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005073-13	A00352-carrier-free	carrier-free	100 ug	$370		Add to Cart

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