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Home / Primary Antibodies / Polyclonal Antibodies

Anti-RAB7A Antibody Picoband®

SKU : BHA21005564

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Mfr.No.	A02409-2, A02409-2-10ug, A02409-2-Biotin, A02409-2-Cy3, A02409-2-Dylight488, A02409-2-Dylight550, A02409-2-Dylight594, A02409-2-FITC, A02409-2-HRP, A02409-2-APC, A02409-2-PE, A02409-2-iFluor647, A02409-2-carrier-free
Alternative Names	nucleoporin 214
Background	Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene. RAB7A functions as a key regulator in endo-lysosomal trafficking, goves early-to-late endosomal maturation, microtubule minus-end as well as plus-end ed endosomal migration and positions, and endosome-lysosome transport through different protein-protein interaction cascades. Furthermore, RAB7A is involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes through modulation of SOX10 and the oncogene MYC. Mutations in the lysosomal pathway result in tumor progression in melanoma cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-RAB7A Antibody Picoband® catalog # A02409-2. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
Host	Rabbit
Immunogen Region	E.coli-derived human RAB7A recombinant protein (Position: A156-R197).
Isotype	Rabbit IgG
Molecular Weight	23 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Nuclear pore complex protein Nup214; 214 kDa nucleoporin; Nucleoporin Nup214; Protein CAN; NUP214; CAIN, CAN, KIAA0023
Tissue Specificity	Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P51149
Gene Id	7879
Gene Name	RAB7A
Subcellular Location	Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Localizes at the cell membrane upon interaction with frizzled family members and promotes their intealization. Localizes to cytoplasmic puncta (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. "Entrez Gene: RAB7A RAB7A, member RAS oncogene family".<br /><br />2. Davies JP, Cotter PD, Ioannou YA (Apr 1997). "Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene". Genomics 41 (1): 1314.<br /><br />3. Kashuba VI, Gizatullin RZ, Protopopov AI, Allikmets R, Korolev S, Li J, Boldog F, Tory K, Zabarovska V, Marcsek Z, Sumegi J, Klein G, Zabarovsky ER, Kisselev L (Dec 1997). "NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukemia and deleted in solid tumors". FEBS Letters 419 (2-3): 1815.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005564-1	A02409-2	-	100 ug	$370		Add to Cart
BHA21005564-2	A02409-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21005564-3	A02409-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005564-4	A02409-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005564-5	A02409-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005564-6	A02409-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005564-7	A02409-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005564-8	A02409-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21005564-9	A02409-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21005564-10	A02409-2-APC	APC	100 ug	$670		Add to Cart
BHA21005564-11	A02409-2-PE	PE	100 ug	$670		Add to Cart
BHA21005564-12	A02409-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005564-13	A02409-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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