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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Rab5/RAB5A Antibody Picoband®

SKU : BHA21000688

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Mfr.No.	PB9787, PB9787-10ug, PB9787-Biotin, PB9787-Cy3, PB9787-Dylight488, PB9787-Dylight550, PB9787-Dylight594, PB9787-FITC, PB9787-HRP, PB9787-APC, PB9787-PE, PB9787-iFluor647, PB9787-carrier-free
Alternative Names	Ras-related protein Rab-5A
Background	RAB5A (Ras-associated protein RAB5A), also called RAB5, is a protein that in humans is encoded by the RAB5A gene. RAB5 is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway. The RAB5A gene is mapped on 3p24.3. RAB5 is indispensable for a form of receptor tyrosine kinase-induced actin remodeling called circular ruffling. It signals to the actin cytoskeleton through RNTRE, a RAB5-specific GTPase-activating protein (GAP). RAB5 activity on phagosome membranes began to increase on disassembly of the actin coat encapsulating phagosomes. In addition, RAB5 activation is either continuous or repetitive for up to 10 minutes, but it ends before the collapse of engulfed apoptotic cells. Expression of a dominant-negative mutant of RAB5 delayed this collapse of apoptotic thymocytes, showing a role for RAB5 in phagosome maturation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Rab5/RAB5A Antibody Picoband® catalog # PB9787. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Rab5, different from the related mouse and rat sequences by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	24 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Ras-related protein Rab-5A;RAB5A;RAB5;
Tissue Specificity	Expressed in breast, placenta, kidney, liver and pancreas. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P20339
Gene Id	5868
Gene Name	RAB5A
Subcellular Location	Cell membrane ; Lipid-anchor ; Cytoplasmic side . Early endosome membrane ; Lipid-anchor . Melanosome. Cytoplasmic vesicle . Cell projection, ruffle . Membrane. Cytoplasm, cytosol. Enriched in stage I melanosomes. Alteates between membrane-bound and cytosolic forms.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. Bucci, C., Parton, R. G., Mather, I. H., Stunnenberg, H., Simons, K., Hoflack, B., Zerial, M. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell 70: 715-728, 1992. 2. Kitano, M., Nakaya, M., Nakamura, T., Nagata, S., Matsuda, M. Imaging of Rab5 activity identifies essential regulators for phagosome maturation. Nature 453: 241-245, 2008. 3. Lanzetti, L., Rybin, V., Malabarba, M. G., Christoforidis, S., Scita, G., Zerial, M., Di Fiore, P. P. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Nature 408: 374-377, 2000.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000688-1	PB9787	100 ug	-	$370		Add to Cart
BHA21000688-2	PB9787-10ug	10 ug	Sample	$99		Add to Cart
BHA21000688-3	PB9787-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000688-4	PB9787-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000688-5	PB9787-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000688-6	PB9787-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000688-7	PB9787-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000688-8	PB9787-FITC	100 ug	FITC	$570		Add to Cart
BHA21000688-9	PB9787-HRP	100 ug	HRP	$570		Add to Cart
BHA21000688-10	PB9787-APC	100 ug	APC	$670		Add to Cart
BHA21000688-11	PB9787-PE	100 ug	PE	$670		Add to Cart
BHA21000688-12	PB9787-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000688-13	PB9787-carrier-free	100 ug	carrier-free	$370		Add to Cart

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