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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PYROXD1 Antibody Picoband®

SKU : BHA21002196

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Mfr.No.	A17214-3, A17214-3-10ug, A17214-3-Biotin, A17214-3-Cy3, A17214-3-Dylight488, A17214-3-Dylight550, A17214-3-Dylight594, A17214-3-FITC, A17214-3-HRP, A17214-3-APC, A17214-3-PE, A17214-3-iFluor647, A17214-3-carrier-free
Alternative Names	pyridine nucleotide-disulphide oxidoreductase domain 1
Background	Pyridine nucleotide-disulphide oxidoreductase domain 1 is a protein that in humans is encoded by the PYROXD1 gene. It is mapped to 12p12.1. This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other proteins. The encoded protein belongs to the class I pyridine nucleotide-disulphide oxidoreductase family but lacks the C-terminal dimerization domain found in other family members and instead has a C-terminal nitrile reductase domain. It localizes to the nucleus and to striated sarcomeric compartments. Naturally occurring mutations in this gene cause early-onset myopathy with intealized nuclei and myofibrillar disorganization. A pseudogene of this gene has been defined on chromosome 11.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PYROXD1 Antibody Picoband® catalog # A17214-3. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in cellular response to oxidative stress.
Host	Rabbit
Immunogen Region	E.coli-derived human PYROXD1 recombinant protein (Position: K48-N230).
Isotype	Rabbit IgG
Molecular Weight	50-56 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; PYROXD1
Tissue Specificity	Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q8WU10
Gene Id	79912
Gene Name	PYROXD1
Subcellular Location	Nucleus. Sarcomere.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. O'Grady, G. L., Best, H. A., Sztal, T. E., Schartner, V., Sanjuan-Vazquez, M., Donkervoort, S., Neto, O. A., Sutton, R. B., Ilkovski, B., Romero, N. B., Stojkovic, T., Dastgir, J., and 30 others. Variants in the oxidoreductase PYROXD1 cause early-onset myopathy with intealized nuclei and myofibrillar disorganization. Am. J. Hum. Genet. 99: 1086-1105, 2016. <br /><br />2. Zhang, J.-L., Zhao, W.-G., Wu, K.-L., Wang, K., Zhang, X., Gu, C.-F., Li, Y., Zhu, Y., Wu, J.-G. Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin. Arch. Virol. 150: 721-741, 2005.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002196-1	A17214-3	-	100 ug	$370		Add to Cart
BHA21002196-2	A17214-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21002196-3	A17214-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002196-4	A17214-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002196-5	A17214-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002196-6	A17214-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002196-7	A17214-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002196-8	A17214-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21002196-9	A17214-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21002196-10	A17214-3-APC	APC	100 ug	$670		Add to Cart
BHA21002196-11	A17214-3-PE	PE	100 ug	$670		Add to Cart
BHA21002196-12	A17214-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002196-13	A17214-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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