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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PTRF/CAVIN1 Antibody Picoband®

SKU : BHA21004974

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Mfr.No.	A31732-2, A31732-2-10ug, A31732-2-Biotin, A31732-2-Cy3, A31732-2-Dylight488, A31732-2-Dylight550, A31732-2-Dylight594, A31732-2-FITC, A31732-2-HRP, A31732-2-APC, A31732-2-PE, A31732-2-iFluor647, A31732-2-carrier-free
Alternative Names	Lymphocyte antigen 6A-2/6E-1
Background	This gene encodes a protein that enables the dissociation of paused teary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PTRF/CAVIN1 Antibody Picoband® catalog # A31732-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	T-cell activation.
Host	Rabbit
Immunogen Region	E.coli-derived human PTRF/CAVIN1 recombinant protein (Position: D47-D390).
Isotype	Rabbit IgG
Molecular Weight	50-55 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Lymphocyte antigen 6A-2/6E-1;Ly-6A.2/Ly-6E.1;Stem cell antigen 1;SCA-1;T-cell-activating protein;TAP;Ly6a;Ly6;
Tissue Specificity	Widely expressed. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q6NZI2
Gene Id	284119
Gene Name	CAVIN1
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.1-0.25 ug/ml, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 1-2 ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Hayashi, Y. K., Matsuda, C., Ogawa, M., Goto, K., Tominaga, K., Mitsuhashi, S., Park, Y.-E., Nonaka, I., Hino-Fukuyo, N., Haginoya, K., Sugano, H., Nishino, I. Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. J. Clin. Invest. 119: 2623-2633, 2009. 2. Hill, M. M., Bastiani, M., Luetterforst, R., Kirkham, M., Kirkham, A., Nixon, S. J., Walser, P., Abankawa, D., Oorschot, V. M. J., Martin, S., Hancock, J. F., Parton, R. G. PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell 132: 113-124, 2008. 3. Jansa, P., Mason, S. W., Hoffmann-Rohrer, U., Grummt, I. Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused teary transcription complexes. EMBO J. 17: 2855-2864, 1998.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004974-1	A31732-2	-	100 ug	$370		Add to Cart
BHA21004974-2	A31732-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004974-3	A31732-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004974-4	A31732-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004974-5	A31732-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004974-6	A31732-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004974-7	A31732-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004974-8	A31732-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004974-9	A31732-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004974-10	A31732-2-APC	APC	100 ug	$670		Add to Cart
BHA21004974-11	A31732-2-PE	PE	100 ug	$670		Add to Cart
BHA21004974-12	A31732-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004974-13	A31732-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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