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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PTEN Antibody Picoband®

SKU : BHA21006334

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Mfr.No.	A00006-5, A00006-5-10ug, A00006-5-Biotin, A00006-5-Cy3, A00006-5-Dylight488, A00006-5-Dylight550, A00006-5-Dylight594, A00006-5-FITC, A00006-5-HRP, A00006-5-APC, A00006-5-PE, A00006-5-iFluor647, A00006-5-carrier-free
Background	Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alteative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
Clonality	Polyclonal
Description	Boster Bio Anti-PTEN Antibody Picoband® catalog # A00006-5. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human PTEN identical to the related mouse and rat sequences.
Molecular Weight	56 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P60484
Gene Id	5728
Gene Name	PTEN

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat

Reference	1. Agrawal, S., Pilarski, R., Eng, C. Different splicing defects lead to differential effects downstream of the lipid and protein phosphatase activities of PTEN. Hum. Molec. Genet. 14: 2459-2468, 2005. 2. Alimonti, A., Carracedo, A., Clohessy, J. G., Trotman, L. C., Nardella, C., Egia, A., Salmena, L., Sampieri, K., Haveman, W. J., Brogi, E., Richardson, A. L., Zhang, J., Pandolfi, P. P. Subtle variations in Pten dose determine cancer susceptibility. Nature Genet. 42: 454-458, 2010. 3. Alvarez-Breckenridge, C. A., Waite, K. A., Eng, C. PTEN regulates phospholipase D and phospholipase C. Hum. Molec. Genet. 16: 1157-1163, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006334-1	A00006-5	-	100 ug	$370		Add to Cart
BHA21006334-2	A00006-5-10ug	Sample	10 ug	$99		Add to Cart
BHA21006334-3	A00006-5-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006334-4	A00006-5-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006334-5	A00006-5-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006334-6	A00006-5-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006334-7	A00006-5-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006334-8	A00006-5-FITC	FITC	100 ug	$570		Add to Cart
BHA21006334-9	A00006-5-HRP	HRP	100 ug	$570		Add to Cart
BHA21006334-10	A00006-5-APC	APC	100 ug	$670		Add to Cart
BHA21006334-11	A00006-5-PE	PE	100 ug	$670		Add to Cart
BHA21006334-12	A00006-5-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006334-13	A00006-5-carrier-free	carrier-free	100 ug	$370		Add to Cart

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