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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PTBP2 Antibody Picoband®

SKU : BHA21002303

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Mfr.No.	A05020-2, A05020-2-10ug, A05020-2-Biotin, A05020-2-Cy3, A05020-2-Dylight488, A05020-2-Dylight550, A05020-2-Dylight594, A05020-2-FITC, A05020-2-HRP, A05020-2-APC, A05020-2-PE, A05020-2-iFluor647, A05020-2-carrier-free
Alternative Names	polypyrimidine tract binding protein 2
Background	Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene. It is mapped to 1p21.3. The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PTBP2 Antibody Picoband® catalog # A05020-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splic
Host	Rabbit
Immunogen Region	E.coli-derived human PTBP2 recombinant protein (Position: M1-A504).
Isotype	Rabbit IgG
Molecular Weight	57 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Polypyrimidine tract-binding protein 2; Neural polypyrimidine tract-binding protein; Neurally-enriched homolog of PTB; PTB-like protein; PTBP2; NPTB; PTB; PTBLP
Tissue Specificity	Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9UKA9
Gene Id	58155
Gene Name	PTBP2
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.25ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Makeyev, E. V., Zhang, J., Carrasco, M. A., Maniatis, T. The microRNA miR-124 promotes neuronal differentiation by triggering brain-specific alteative pre-mRNA splicing. Molec. Cell 27: 435-448, 2007. <br /><br />2. Rahman, L., Bliskovski, V., Kaye, F. J., Zajac-Kaye, M. Evolutionary conservation of a 2-kb intronic sequence flanking a tissue-specific alteative exon in the PTBP2 gene. Genomics 83: 76-84, 2004.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002303-1	A05020-2	-	100 ug	$370		Add to Cart
BHA21002303-2	A05020-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002303-3	A05020-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002303-4	A05020-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002303-5	A05020-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002303-6	A05020-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002303-7	A05020-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002303-8	A05020-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002303-9	A05020-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002303-10	A05020-2-APC	APC	100 ug	$670		Add to Cart
BHA21002303-11	A05020-2-PE	PE	100 ug	$670		Add to Cart
BHA21002303-12	A05020-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002303-13	A05020-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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