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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Protein NDRG1 NDRG1 Antibody Picoband®

SKU : BHA21006777

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Mfr.No.	PA1416, PA1416-10ug, PA1416-Biotin, PA1416-Cy3, PA1416-Dylight488, PA1416-Dylight550, PA1416-Dylight594, PA1416-FITC, PA1416-HRP, PA1416-APC, PA1416-PE, PA1416-iFluor647, PA1416-carrier-free
Alternative Names	Protein NDRG1
Background	Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene. It is a member of the N-myc downregulated gene family which belong to the alpha/beta hydrolase superfamily. The NDRG1 gene is mapped to chromosome 8q24. It has got a deduced 394 amino acid protein with a molecular mass of 43kD. NDRG1 is expressed in the cytoplasm and basolateral membranes of gut lumen surface epithelial cells. The protein appears to play a vital role in growth arrest and cell differentiation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Protein NDRG1 NDRG1 Antibody catalog # PA1416. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking,
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human NDRG1.
Isotype	Rabbit IgG
Molecular Weight	36 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Protein NDRG1;Differentiation-related gene 1 protein;DRG-1;N-myc downstream-regulated gene 1 protein;Nickel-specific induction protein Cap43;Reducing agents and tunicamycin-responsive protein;RTP;Rit42;NDRG1;CAP43, DRG1, RTP;
Tissue Specificity	Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q92597
Gene Name	NDRG1
Sequence	Belongs to the NDRG family.
Subcellular Location	Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. van Belzen N, Dinjens WN, Diesveld MP, Groen NA, van der Made AC, Nozawa Y, Vlietstra R, Trapman J, Bosman FT (Sep 1997). "A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms". Lab Invest 77 (1): 8592. PMID 9251681. <br /><br />2. Kokame K, Kato H, Miyata T (Jan 1997). "Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes". J Biol Chem 271 (47): 2965965. <br /><br />3. Zhang J, Chen S, Zhang W, Zhang J, Liu X, Shi H, Che H, Wang W, Li F, Yao L (Jun 2008). "Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region". Gene 417 (1-2): 512.<br /><br />4. "Entrez Gene: NDRG1 N-myc downstream regulated gene 1".<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006777-1	PA1416	-	100 ug	$370		Add to Cart
BHA21006777-2	PA1416-10ug	Sample	10 ug	$99		Add to Cart
BHA21006777-3	PA1416-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006777-4	PA1416-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006777-5	PA1416-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006777-6	PA1416-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006777-7	PA1416-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006777-8	PA1416-FITC	FITC	100 ug	$570		Add to Cart
BHA21006777-9	PA1416-HRP	HRP	100 ug	$570		Add to Cart
BHA21006777-10	PA1416-APC	APC	100 ug	$670		Add to Cart
BHA21006777-11	PA1416-PE	PE	100 ug	$670		Add to Cart
BHA21006777-12	PA1416-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006777-13	PA1416-carrier-free	carrier-free	100 ug	$370		Add to Cart

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