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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Protein C/PROC Antibody Picoband®

SKU : BHA21006979

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Mfr.No.	PA1682, PA1682-10ug, PA1682-Biotin, PA1682-Cy3, PA1682-Dylight488, PA1682-Dylight550, PA1682-Dylight594, PA1682-FITC, PA1682-HRP, PA1682-APC, PA1682-PE, PA1682-iFluor647, PA1682-carrier-free
Alternative Names	Vitamin K-dependent protein C
Background	Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. The PROC gene contains 8 exons and spans about 11 kb by Foster et al. The conversion of protein C to a protease with anticoagulant function by thrombin requires as a cofactor thrombomodulin, an endothelial cell membrane protein. Riewald et al. demonstrated that activated protein C uses the endothelial cell protein C receptor as a coreceptor for cleavage of protease-activated receptor-1 on endothelial cells. Faust et al. demonstrated that the endothelial pathways required for protein C activation are impaired in severe meningococcal sepsis. They stated that improvement in the outcome of children with meningococcal sepsis who were treated with unactivated protein C concentrates had been described in case reports and in 1 uncontrolled series.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Protein C/PROC Antibody catalog # PA1682. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Protein C.
Isotype	Rabbit IgG
Molecular Weight	36 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Vitamin K-dependent protein C;3.4.21.69;Anticoagulant protein C;Autoprothrombin IIA;Blood coagulation factor XIV;Vitamin K-dependent protein C light chain;Vitamin K-dependent protein C heavy chain;Activation peptide;PROC;
Tissue Specificity	Plasma; synthesized in the liver.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P04070
Gene Name	PROC
Sequence	Belongs to the peptidase S1 family.
Subcellular Location	Secreted .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, ICC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human<br> Immunocytochemistry, 0.5-1ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human

Reference	1. Allaart, C. F., Poort, S. R., Rosendaal, F. R., Reitsma, P. H., Bertina, R. M., Briet, E. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet 341: 134-138, 1993.<br /><br />2. Beckmann, R. J., Schmidt, R. J., Santerre, R. F., Plutzky, J., Crabtree, G. R., Long, G. L. The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs. Nucleic Acids Res. 13: 5233-5247, 1985.<br /><br />3. Berg, L.-P., Scopes, D. A., Alhaq, A., Kakkar, V. V., Cooper, D. N. Disruption of a binding site for hepatocyte nuclear factor 1 in the protein C gene promoter is associated with hereditary thrombophilia. Hum. Molec. Genet. 3: 2147-2152, 1994.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006979-1	PA1682	-	100 ug	$370		Add to Cart
BHA21006979-2	PA1682-10ug	Sample	10 ug	$99		Add to Cart
BHA21006979-3	PA1682-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006979-4	PA1682-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006979-5	PA1682-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006979-6	PA1682-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006979-7	PA1682-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006979-8	PA1682-FITC	FITC	100 ug	$570		Add to Cart
BHA21006979-9	PA1682-HRP	HRP	100 ug	$570		Add to Cart
BHA21006979-10	PA1682-APC	APC	100 ug	$670		Add to Cart
BHA21006979-11	PA1682-PE	PE	100 ug	$670		Add to Cart
BHA21006979-12	PA1682-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006979-13	PA1682-carrier-free	carrier-free	100 ug	$370		Add to Cart

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