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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Progesterone Receptor/PGR Antibody Picoband®

SKU : BHA21007472

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Mfr.No.	PB9009, PB9009-10ug, PB9009-Biotin, PB9009-Cy3, PB9009-Dylight488, PB9009-Dylight550, PB9009-Dylight594, PB9009-FITC, PB9009-HRP, PB9009-APC, PB9009-PE, PB9009-iFluor647, PB9009-carrier-free
Alternative Names	Progesterone receptor
Background	The progesterone receptor (PR) is an intracellular steroid receptor that specially binds progesterone in humans. PR has been a member of the steroid receptor superfamily. It is encoded by a single PGR gene residing on chromosome 11q22. The PGR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. It can be observed in human breast tissues. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Progesterone Receptor/PGR Antibody Picoband® catalog # PB9009. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signa
Host	Rabbit
Immunogen Region	E.coli-derived human Progesterone Receptor recombinant protein (Position: M595-K933). Human Progesterone Receptor shares 95% and 94% amino acid (aa) sequences identity with mouse and rat Progesterone Receptor, respectively.
Isotype	Rabbit IgG
Molecular Weight	90 kDa (PR-A), 118 kDa (PR-B)
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Progesterone receptor;PR;Nuclear receptor subfamily 3 group C member 3;PGR;NR3C3;
Tissue Specificity	Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P06401
Gene Name	PGR
Sequence	Belongs to the nuclear hormone receptor family. NR3 subfamily.
Subcellular Location	Nucleus. Cytoplasm. Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G (1) and G (2)/M phases.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br>

Reference	1. Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E (March 1987). "Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA". Biochem. Biophys. Res. Commun. 143 (2): 7408. <br /><br />2. Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW (May 1987). "The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2". Proc. Natl. Acad. Sci. U.S.A. 84 (9): 287781. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240. <br /><br />3. Nishihara T, Kitaura M, Imagawa M, Nishikawa J (1995). "Vitamin D receptor contains multiple dimerization interfaces that are functionally different". Nucleic Acids Res. 23 (4): 606611. <br /><br />4. Schmitt J, De Vos P, Verhoeven G, Stunnenberg HG (1994). "Human androgen receptor expressed in HeLa cells activates transcription in vitro". Nucleic Acids Res. 22 (7): 11611166. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007472-1	PB9009	-	100 ug	$370		Add to Cart
BHA21007472-2	PB9009-10ug	Sample	10 ug	$99		Add to Cart
BHA21007472-3	PB9009-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007472-4	PB9009-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007472-5	PB9009-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007472-6	PB9009-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007472-7	PB9009-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007472-8	PB9009-FITC	FITC	100 ug	$570		Add to Cart
BHA21007472-9	PB9009-HRP	HRP	100 ug	$570		Add to Cart
BHA21007472-10	PB9009-APC	APC	100 ug	$670		Add to Cart
BHA21007472-11	PB9009-PE	PE	100 ug	$670		Add to Cart
BHA21007472-12	PB9009-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007472-13	PB9009-carrier-free	carrier-free	100 ug	$370		Add to Cart

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