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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Profilin 2/PFN2 Antibody Picoband®

SKU : BHA21007360

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Mfr.No.	PA2162, PA2162-10ug, PA2162-Biotin, PA2162-Cy3, PA2162-Dylight488, PA2162-Dylight550, PA2162-Dylight594, PA2162-FITC, PA2162-HRP, PA2162-APC, PA2162-PE, PA2162-iFluor647, PA2162-carrier-free
Alternative Names	Profilin-2
Background	Profilin-2, also called PFN2, is a protein that in humans is encoded by the PFN2 gene. The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. This gene is mapped to 3q25.1. It is though to regulate actin polymerization in response to extracellular signals. There are two alteatively spliced transcript variants encoding different isoforms described for this gene. It binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Profilin 2/PFN2 Antibody catalog # PA2162. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Profilin 2, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	15 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Profilin-2;Profilin II;PFN2;
Tissue Specificity	Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P35080
Gene Name	PFN2
Sequence	Contains 17 laminin EGF-like domains.
Subcellular Location	Cytoplasm, cytoskeleton.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human

Reference	1. Gieselmann, R., Kwiatkowski, D. J., Janmey, P. A., Witke, W. Distinct biochemical characteristics of the two human profilin isoforms. Europ. J. Biochem. 229: 621-628, 1995. <br /><br />2. Joensuu, T., Blanco, G., Pakarinen, L., Sistonen, P., Kaariainen, H., Brown, S., de la Chapelle, A., Sankila, E.-M. Refined mapping of the Usher syndrome type III locus on chromosome 3, exclusion of candidate genes, and identification of the putative mouse homologous region. Genomics 38: 255-263, 1996.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007360-1	PA2162	-	100 ug	$370		Add to Cart
BHA21007360-2	PA2162-10ug	Sample	10 ug	$99		Add to Cart
BHA21007360-3	PA2162-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007360-4	PA2162-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007360-5	PA2162-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007360-6	PA2162-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007360-7	PA2162-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007360-8	PA2162-FITC	FITC	100 ug	$570		Add to Cart
BHA21007360-9	PA2162-HRP	HRP	100 ug	$570		Add to Cart
BHA21007360-10	PA2162-APC	APC	100 ug	$670		Add to Cart
BHA21007360-11	PA2162-PE	PE	100 ug	$670		Add to Cart
BHA21007360-12	PA2162-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007360-13	PA2162-carrier-free	carrier-free	100 ug	$370		Add to Cart

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