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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Prion protein PrP/PRNP Antibody Picoband®

SKU : BHA21007065

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Mfr.No.	PA1795, PA1795-10ug, PA1795-Biotin, PA1795-Cy3, PA1795-Dylight488, PA1795-Dylight550, PA1795-Dylight594, PA1795-FITC, PA1795-HRP, PA1795-APC, PA1795-PE, PA1795-iFluor647, PA1795-carrier-free
Alternative Names	Major prion protein
Background	PRNP (prion protein), also known as CD230 and PRP, is a protein that in humans is encoded by the PRNP gene. The major prion protein is expressed in the brain and several other tissues. Expression is most predominant in the nervous system but occurs in many other tissues throughout the body. Puckett et al. (1991)identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PRNP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru. PRNP is highly conserved through mammals, lending credence to application of conclusions from test animals such as mice. Comparison between primates is especially similar, ranging from 92.9-99.6% similarity in amino acid sequences.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Prion protein PrP/PRNP Antibody catalog # PA1795. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of mouse PRNP, identical to the related rat sequence.
Isotype	Rabbit IgG
Molecular Weight	28 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Major prion protein;PrP;PrP27-30;PrP33-35C;CD230;Pp;P-p, Prp;
Tissue Specificity	Highly expressed in the brain, lung, kidney and heart. Expressed at low levels in the liver and spleen. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P04925
Gene Name	PRNP
Subcellular Location	Cell membrane ; Lipid-anchor, GPI-anchor . Golgi apparatus . Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of CU (2+), to vesicles in para- and perinuclear regions, where both proteins undergo intealization. Heparin displaces PRNP from lipid rafts and promotes endocytosis. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Rat, Mouse, By Heat <br>Weste blot, 0.1-0.5ug/ml, Rat, Mouse<br>

Reference	1. Bounhar, Y., Zhang, Y., Goodyer, C. G., LeBlanc, A.Prion protein protects human neurons against Bax-mediated apoptosis.J. Biol. Chem. 276: 39145-39149, 2001.<br /><br />2. Brown, P., Galvez, S., Goldfarb, L. G., Nieto, A., Cartier, L., Gibbs, C. J., Jr., Gajdusek, D. C.Familial Creutzfeldt-Jakob disease in Chile is associated with the codon 200 mutation of the PRNP amyloid precursor gene on chromosome 20.J. Neurol. Sci. 112: 65-67, 1992.<br /><br />3. Puckett, C., Concannon, P., Casey, C., Hood, L.Genomic structure of the human prion protein gene.Am. J. Hum. Genet. 49: 320-329, 1991.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007065-1	PA1795	-	100 ug	$370		Add to Cart
BHA21007065-2	PA1795-10ug	Sample	10 ug	$99		Add to Cart
BHA21007065-3	PA1795-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007065-4	PA1795-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007065-5	PA1795-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007065-6	PA1795-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007065-7	PA1795-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007065-8	PA1795-FITC	FITC	100 ug	$570		Add to Cart
BHA21007065-9	PA1795-HRP	HRP	100 ug	$570		Add to Cart
BHA21007065-10	PA1795-APC	APC	100 ug	$670		Add to Cart
BHA21007065-11	PA1795-PE	PE	100 ug	$670		Add to Cart
BHA21007065-12	PA1795-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007065-13	PA1795-carrier-free	carrier-free	100 ug	$370		Add to Cart

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