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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PPP2R1A Antibody Picoband®

SKU : BHA21003720

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Mfr.No.	A02822-2, A02822-2-10ug, A02822-2-Biotin, A02822-2-Cy3, A02822-2-Dylight488, A02822-2-Dylight550, A02822-2-Dylight594, A02822-2-FITC, A02822-2-HRP, A02822-2-APC, A02822-2-PE, A02822-2-iFluor647, A02822-2-carrier-free
Alternative Names	V-set domain containing T cell activation inhibitor 1
Background	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alteatively spliced transcript variants have been described.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PPP2R1A Antibody Picoband® catalog # A02822-2. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regul
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human PPP2R1A, which shares 95.2% amino acid (aa) sequence identity with mouse PPP2R1A, respectively.
Isotype	Rabbit IgG
Molecular Weight	65 kDa
Reactivity	Human, Monkey, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	V-set domain-containing T-cell activation inhibitor 1; B7 homolog 4; B7-H4; B7h.5; Immune costimulatory protein B7-H4; Protein B7S1; T-cell costimulatory molecule B7x; VTCN1; B7H4; UNQ659; PRO1291
Tissue Specificity	Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P30153
Gene Id	5518
Gene Name	PPP2R1A
Subcellular Location	Cell membrane. Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human, Monkey, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human, Mouse, Rat

Reference	1. Deciphering Developmental Disorders Study. Large-scale discovery of novel genetic causes of developmental disorders. Nature 519: 223-228, 2015. 2. Everett, A. D., Xue, C., Stoops, T. Developmental expression of protein phosphatase 2A in the kidney. J. Am. Soc. Nephrol. 10: 1737-1745, 1999. 3. Groves, M. R., Hanlon, N., Turowski, P., Hemmings, B. A., Barford, D. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell 96: 99-110, 1999.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003720-1	A02822-2	-	100 ug	$370		Add to Cart
BHA21003720-2	A02822-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003720-3	A02822-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003720-4	A02822-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003720-5	A02822-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003720-6	A02822-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003720-7	A02822-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003720-8	A02822-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003720-9	A02822-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003720-10	A02822-2-APC	APC	100 ug	$670		Add to Cart
BHA21003720-11	A02822-2-PE	PE	100 ug	$670		Add to Cart
BHA21003720-12	A02822-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003720-13	A02822-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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