JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
orders@biohippo.com

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Primary Antibodies / Polyclonal Antibodies

Anti-Polycomb complex protein BMI-1 Bmi1 Antibody Picoband®

SKU : BHA21007075

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Request More Infos

Boster

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	PA1807, PA1807-10ug, PA1807-Biotin, PA1807-Cy3, PA1807-Dylight488, PA1807-Dylight550, PA1807-Dylight594, PA1807-FITC, PA1807-HRP, PA1807-APC, PA1807-PE, PA1807-iFluor647, PA1807-carrier-free
Alternative Names	Polycomb complex protein BMI-1
Background	BMI1 (BMI1 polycomb ring finger oncogene),also known as RNF51, is a protein which in humans is encoded by the BMI1 gene. The Bmi1 gene is highly conserved in evolution as indicated by zoo blot hybridization with Bmi1 probes corresponding to the protein-encoding domain. By fluorescence in situ hybridization, the human BMI1 gene is assigned to chromosome 10p13. BMI1 has a key role in regulating the proliferative activity of normal stem and progenitor cells. Most importantly, they provided evidence that the proliferative potential of leukemic stem and progenitor cells lacking BMI1 is compromised because they eventually undergo proliferation arrest and show signs of differentiation and apoptosis, leading to transplant failure of the leukemia. Complementation studies showed that BMI1 completely rescues these proliferative defects. Deletion analysis showed that the RING finger and helix-tu-helix domains of BMI1 were required for life span extension and repression of the tumor suppressor p16 (INK4). BMI1 selectively extended the life span of these cultures. Confocal microscopy showed that BMI1 transiently colocalized with centromeres during interphase in HeLa cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Polycomb complex protein BMI-1 Bmi1 Antibody catalog # PA1807. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Bmi1, different from the related mouse sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	37 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Polycomb complex protein BMI-1;Polycomb group RING finger protein 4;RING finger protein 51;BMI1;PCGF4, RNF51;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P35226
Gene Name	BMI1
Sequence	Contains 1 RING-type zinc finger.
Subcellular Location	Nucleus. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Alkema, M. J., van der Lugt, N. M. T., Bobeldijk, R. C., Bes, A., van Lohuizen, M. Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Nature 374: 724-727, 1995.<br /><br />2. Chagraoui, J., Niessen, S. L., Lessard, J., Girard, S., Coulombe, P., Sauvageau, M., Meloche, S., Sauvageau, G. E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells. Genes Dev. 20: 2110-2120, 2006.<br /><br />3. Leung, C., Lingbeek, M., Shakhova, O., Liu, J., Tanger, E., Saremaslani, P., van Lohuizen, M., Marino, S. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 428: 337-341, 2004.<br /><br />

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007075-1	PA1807	-	100 ug	$370		Add to Cart
BHA21007075-2	PA1807-10ug	Sample	10 ug	$99		Add to Cart
BHA21007075-3	PA1807-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007075-4	PA1807-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007075-5	PA1807-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007075-6	PA1807-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007075-7	PA1807-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007075-8	PA1807-FITC	FITC	100 ug	$570		Add to Cart
BHA21007075-9	PA1807-HRP	HRP	100 ug	$570		Add to Cart
BHA21007075-10	PA1807-APC	APC	100 ug	$670		Add to Cart
BHA21007075-11	PA1807-PE	PE	100 ug	$670		Add to Cart
BHA21007075-12	PA1807-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007075-13	PA1807-carrier-free	carrier-free	100 ug	$370		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.