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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Plectin Antibody Picoband®

SKU : BHA21000325

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Mfr.No.	PB9430, PB9430-10ug, PB9430-Biotin, PB9430-Cy3, PB9430-Dylight488, PB9430-Dylight550, PB9430-Dylight594, PB9430-FITC, PB9430-HRP, PB9430-APC, PB9430-PE, PB9430-iFluor647, PB9430-carrier-free
Alternative Names	Plectin
Background	Plectin, known as PLEC, is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes. Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail, revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alteatively splice ly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alteative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alteative 5' exons found in mouse and rat; exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse, rat, and human. The short alteative amino-terminal sequences encoded by the different first exons the targeting of the various isoforms to distinct subcellular locations. As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development, it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Plectin Antibody Picoband® catalog # PB9430. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filam
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Plectin, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	532 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Plectin;PCN;PLTN;Hemidesmosomal protein 1;HD1;Plectin-1;PLEC;PLEC1;
Tissue Specificity	Widely expressed with highest levels in muscle, heart, placenta and spinal cord.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q15149
Gene Id	5339
Gene Name	PLEC
Sequence	Belongs to the plakin or cytolinker family.
Subcellular Location	Cytoplasm, cytoskeleton . Cell junction, hemidesmosome .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Mouse, Rat, By Heat Immunocytochemistry/Immunofluorescence, 5ug/ml, Human

Reference	1. Svitkina TM, Verkhovsky AB, Borisy GG (Nov 1996). "Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton". The Joual of Cell Biology135 (4): 9911007. 2. Wiche G (Sep 1998). "Role of plectin in cytoskeleton organization and dynamics"(ABSTRACT). Joual of Cell Science. 111 ( Pt 17) (17): 247786.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000325-1	PB9430	100 ug	-	$370		Add to Cart
BHA21000325-2	PB9430-10ug	10 ug	Sample	$99		Add to Cart
BHA21000325-3	PB9430-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000325-4	PB9430-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000325-5	PB9430-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000325-6	PB9430-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000325-7	PB9430-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000325-8	PB9430-FITC	100 ug	FITC	$570		Add to Cart
BHA21000325-9	PB9430-HRP	100 ug	HRP	$570		Add to Cart
BHA21000325-10	PB9430-APC	100 ug	APC	$670		Add to Cart
BHA21000325-11	PB9430-PE	100 ug	PE	$670		Add to Cart
BHA21000325-12	PB9430-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000325-13	PB9430-carrier-free	100 ug	carrier-free	$370		Add to Cart

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