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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PKR/EIF2AK2 Antibody Picoband®

SKU : BHA21007247

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Mfr.No.	PA2025, PA2025-10ug, PA2025-Biotin, PA2025-Cy3, PA2025-Dylight488, PA2025-Dylight550, PA2025-Dylight594, PA2025-FITC, PA2025-HRP, PA2025-APC, PA2025-PE, PA2025-iFluor647, PA2025-carrier-free
Alternative Names	Interferon-induced, double-stranded RNA-activated protein kinase
Background	EIF2AK2 (Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2), also called PKR, is an enzyme that in humans is encoded by the EIF2AK2 gene. Activation of EIF2AK2 allows the kinase to phosphorylate its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2, leading to the inhibition of protein synthesis (summary by Kuhen et al., 1996). By FISH analysis, Squire et al. (1993) assigned the EIF2AK2 gene to the boundary between chromosome 2p22-p21. Ben-Asouli et al. (2002) showed that human gamma-interferon mRNA uses local activation of PKR in the cell to control its own translation yield. IFNG mRNA was found to activate PKR through a pseudoknot in its 5-prime untranslated region. Taylor et al. (1999) studied the mechanism underlying the resistance of hepatitis C virus (HCV) to interferon. They demonstrated that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor EIF2-alpha, a target of PKR. E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-PKR/EIF2AK2 Antibody catalog # PA2025. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts it
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human PKR.
Isotype	Rabbit IgG
Molecular Weight	94 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Interferon-induced, double-stranded RNA-activated protein kinase;2.7.11.1;Eukaryotic translation initiation factor 2-alpha kinase 2;eIF-2A protein kinase 2;Interferon-inducible RNA-dependent protein kinase;P1/eIF-2A protein kinase;Protein kinase RNA-activated;PKR;Protein kinase R ;Tyrosine-protein kinase EIF2AK2;2.7.10.2;p68 kinase;EIF2AK2;PKR, PRKR;
Tissue Specificity	Highly expressed in thymus, spleen and bone marrow compared to non-hematopoietic tissues such as small intestine, liver, or kidney tissues. Colocalizes with GSK3B and TAU in the Alzheimer disease (AD) brain. Elevated levels seen in breast and colon carcinomas,and which correlates with tumor progression and invasiveness or risk of progression. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P19525
Gene Name	EIF2AK2
Sequence	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt-Jakob disease patients.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Ben-Asouli, Y., Banai, Y., Pel-Or, Y., Shir, A., Kaempfer, R. Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR. Cell 108: 221-232, 2002. <br /><br />2. Kuhen, K. L., Shen, X., Carlisle, E. R., Richardson, A.L., Weier, H.-U. G., Tanaka, H., Samuel, C. E. Structural organization of the human gene (PKR) encoding an interferon-inducible RNA-dependent protein kinase (PKR) and differences from its mouse homolog. Genomics 36: 197-201, 1996. <br /><br />3. Squire, J., Meurs, E. F., Chong, K. L., McMillan, N. A. J., Hovanessian, A. G., Williams, B. R. G. Localization of the human interferon-induced, ds-RNA activated p68 kinase gene (PRKR) to chromosome 2p21-p22. Genomics 16: 768-770, 1993.<br /><br />4. Taylor, D. R., Shi, S. T., Romano, P. R., Barber, G. N., Lal, M. M. C. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science 285: 107-110, 1999.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007247-1	PA2025	-	100 ug	$370		Add to Cart
BHA21007247-2	PA2025-10ug	Sample	10 ug	$99		Add to Cart
BHA21007247-3	PA2025-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007247-4	PA2025-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007247-5	PA2025-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007247-6	PA2025-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007247-7	PA2025-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007247-8	PA2025-FITC	FITC	100 ug	$570		Add to Cart
BHA21007247-9	PA2025-HRP	HRP	100 ug	$570		Add to Cart
BHA21007247-10	PA2025-APC	APC	100 ug	$670		Add to Cart
BHA21007247-11	PA2025-PE	PE	100 ug	$670		Add to Cart
BHA21007247-12	PA2025-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007247-13	PA2025-carrier-free	carrier-free	100 ug	$370		Add to Cart

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