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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PINX1 Antibody Picoband®

SKU : BHA21000394

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Mfr.No.	PB9498, PB9498-10ug, PB9498-Biotin, PB9498-Cy3, PB9498-Dylight488, PB9498-Dylight550, PB9498-Dylight594, PB9498-FITC, PB9498-HRP, PB9498-APC, PB9498-PE, PB9498-iFluor647, PB9498-carrier-free
Alternative Names	PIN2/TERF1-interacting telomerase inhibitor 1
Background	PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed TERT protein so that it cannot associate with the telomerase template RNA, which prevents telomerase from being assembled. However, in humans, PINX1 impedes already assembled telomerase.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-PINX1 Antibody Picoband® catalog # PB9498. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human PINX1, different from the related mouse and rat sequences by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	37 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	PIN2/TERF1-interacting telomerase inhibitor 1;Liver-related putative tumor suppressor;Pin2-interacting protein X1;Protein 67-11-3;TRF1-interacting protein 1;PINX1;LPTL, LPTS;
Tissue Specificity	Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q96BK5
Gene Id	54984
Gene Name	PINX1
Sequence	Belongs to the PINX1 family.
Subcellular Location	Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Western blot, 0.1-0.5ug/ml, Human

Reference	1. Banik, S.S.R.; Counter, C.M. (September 2004). "Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTR". Journal of Biological Chemistry. 2. Zhou, X Z; Lu K P (Nov 2001). "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor". Cell (United States) 107 (3): 34759.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000394-1	PB9498	100 ug	-	$370		Add to Cart
BHA21000394-2	PB9498-10ug	10 ug	Sample	$99		Add to Cart
BHA21000394-3	PB9498-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000394-4	PB9498-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000394-5	PB9498-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000394-6	PB9498-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000394-7	PB9498-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000394-8	PB9498-FITC	100 ug	FITC	$570		Add to Cart
BHA21000394-9	PB9498-HRP	100 ug	HRP	$570		Add to Cart
BHA21000394-10	PB9498-APC	100 ug	APC	$670		Add to Cart
BHA21000394-11	PB9498-PE	100 ug	PE	$670		Add to Cart
BHA21000394-12	PB9498-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000394-13	PB9498-carrier-free	100 ug	carrier-free	$370		Add to Cart

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