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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Phospholamban/PLN Antibody Picoband®

SKU : BHA21006706

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Mfr.No.	PA1309, PA1309-10ug, PA1309-Biotin, PA1309-Cy3, PA1309-Dylight488, PA1309-Dylight550, PA1309-Dylight594, PA1309-FITC, PA1309-HRP, PA1309-APC, PA1309-PE, PA1309-iFluor647, PA1309-carrier-free
Alternative Names	Cardiac phospholamban
Background	Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca (2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. McTiean et al. (1999) observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Phospholamban/PLN Antibody catalog # PA1309. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca (2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Mod
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human PLN, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	24 kDa, 12 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cardiac phospholamban;PLB;PLN;PLB;
Tissue Specificity	Heart muscle (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P26678
Gene Name	PLN
Sequence	Belongs to the peptidase C14A family.
Subcellular Location	Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane ; Single- pass membrane protein . Endoplasmic reticulum membrane; Single-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat<br>

Reference	1. Rodriguez P, Kranias EG (December 2005). "Phospholamban: a key determinant of cardiac function and dysfunction". Arch Mal Coeur Vaiss 98 (12): 123943.<br /><br />2. McTiean, C. F.; Frye, C. S.; Lemster, B. H.; Kinder, E. A.; Ogletree-Hughes, M. L.; Moravec, C. S.; Feldman, A. M. : The human phospholamban gene: structure and expression. J. Molec. Cell Cardiol. 31: 679-692, 1999.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006706-1	PA1309	-	100 ug	$370		Add to Cart
BHA21006706-2	PA1309-10ug	Sample	10 ug	$99		Add to Cart
BHA21006706-3	PA1309-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006706-4	PA1309-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006706-5	PA1309-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006706-6	PA1309-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006706-7	PA1309-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006706-8	PA1309-FITC	FITC	100 ug	$570		Add to Cart
BHA21006706-9	PA1309-HRP	HRP	100 ug	$570		Add to Cart
BHA21006706-10	PA1309-APC	APC	100 ug	$670		Add to Cart
BHA21006706-11	PA1309-PE	PE	100 ug	$670		Add to Cart
BHA21006706-12	PA1309-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006706-13	PA1309-carrier-free	carrier-free	100 ug	$370		Add to Cart

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