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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PHC1 Antibody Picoband®

SKU : BHA21005781

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Mfr.No.	A06437-3, A06437-3-10ug, A06437-3-Biotin, A06437-3-Cy3, A06437-3-Dylight488, A06437-3-Dylight550, A06437-3-Dylight594, A06437-3-FITC, A06437-3-HRP, A06437-3-APC, A06437-3-PE, A06437-3-iFluor647, A06437-3-carrier-free
Alternative Names	Serine/threonine-protein kinase AtPK1/AtPK6
Background	Polyhomeotic-like protein 1 is a protein that in humans is encoded by the PHC1 gene. This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.
Clonality	Polyclonal
Cross Reactivity	No cross reactivity with other proteins.
Description	Boster Bio Anti-PHC1 Antibody Picoband® catalog # A06437-3. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and r
Host	Rabbit
Immunogen Region	E.coli-derived human PHC1 recombinant protein (Position: R23-K642). Human PHC1 shares 93.6% amino acid (aa) sequence identity with mouse PHC1.
Isotype	IgG
Molecular Weight	140 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Tissue Specificity	Expressed in all tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P78364
Gene Id	1911
Gene Name	PHC1
Subcellular Location	Cytoplasm. Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Alkema, M. J., Bronk, M., Verhoeven, E., Otte, A., van't Veer, L. J., Bes, A., van Lohuizen, M. Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex. Genes Dev. 11: 226-240, 1997. <br /><br />2. Awad, S., Al-Dosari, M. S., Al-Yacoub, N., Colak, D., Salih, M. A., Alkuraya, F. S., Poizat, C. Mutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesis. Hum. Molec. Genet. 22: 2200-2213, 2013. <br /><br />3. Gunster, M. J., Satijn, D. P. E., Hamer, K. M., den Blaauwen, J. L., de Bruijn, D., Alkema, M. J., van Lohuizen, M., van Driel, R., Otte, A. P. Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. Molec. Cell. Biol. 17: 2326-2335, 1997.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005781-1	A06437-3	-	100 ug	$370		Add to Cart
BHA21005781-2	A06437-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21005781-3	A06437-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005781-4	A06437-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005781-5	A06437-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005781-6	A06437-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005781-7	A06437-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005781-8	A06437-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21005781-9	A06437-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21005781-10	A06437-3-APC	APC	100 ug	$670		Add to Cart
BHA21005781-11	A06437-3-PE	PE	100 ug	$670		Add to Cart
BHA21005781-12	A06437-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005781-13	A06437-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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