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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PFKFB2 Antibody Picoband®

SKU : BHA21003298

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Mfr.No.	A05977, A05977-10ug, A05977-Biotin, A05977-Cy3, A05977-Dylight488, A05977-Dylight550, A05977-Dylight594, A05977-FITC, A05977-HRP, A05977-APC, A05977-PE, A05977-iFluor647, A05977-carrier-free
Alternative Names	Long-chain-fatty-acid--CoA ligase 3
Background	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene. The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PFKFB2 Antibody Picoband® catalog # A05977. Tested in ELISA, Flow Cytometry, IF, ICC, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapent
Host	Rabbit
Immunogen Region	E.coli-derived human PFKFB2 recombinant protein (Position: A4-D505).
Isotype	Rabbit IgG
Molecular Weight	58 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Long-chain-fatty-acid--CoA ligase 3;6.2.1.3;Long-chain acyl-CoA synthetase 3;LACS 3;ACSL3;ACS3, FACL3, LACS3;
Tissue Specificity	Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Uniprot	O60825
Gene Id	5208
Gene Name	PFKFB2
Subcellular Location	Mitochondrion outer membrane ; Single-pass type III membrane protein . Peroxisome membrane ; Single-pass type III membrane protein . Microsome membrane ; Single-pass type III membrane protein . Endoplasmic reticulum membrane ; Single-pass type III membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Heine-Suner, D., Diaz-Guillen, M. A., de Villena, F. P.-M., Robledo, M., Benitez, J., Rodriguez de Cordoba, S. A high-resolution map of the regulator of the complement activation gene cluster on 1q32 that integrates new genes and markers. Immunogenetics 45: 422-427, 1997. <br /><br />2. Heine-Suner, D., Diaz-Guillen, M. A., Lange, A. J., Rodriguez de Cordoba, S. Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2). Europ. J. Biochem. 254: 103-110, 1998. <br /><br />3. Hilliker, C. E., Darville, M. I., Aly, M. S., Chikri, M., Szpirer, C., Marynen, P., Rousseau, G. G., Cassiman, J.-J. Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization. Genomics 10: 867-873, 1991.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003298-1	A05977	-	100 ug	$370		Add to Cart
BHA21003298-2	A05977-10ug	Sample	10 ug	$99		Add to Cart
BHA21003298-3	A05977-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003298-4	A05977-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003298-5	A05977-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003298-6	A05977-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003298-7	A05977-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003298-8	A05977-FITC	FITC	100 ug	$570		Add to Cart
BHA21003298-9	A05977-HRP	HRP	100 ug	$570		Add to Cart
BHA21003298-10	A05977-APC	APC	100 ug	$670		Add to Cart
BHA21003298-11	A05977-PE	PE	100 ug	$670		Add to Cart
BHA21003298-12	A05977-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003298-13	A05977-carrier-free	carrier-free	100 ug	$370		Add to Cart

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