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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PF4 Antibody Picoband®

SKU : BHA21000916

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Mfr.No.	PB10011, PB10011-10ug, PB10011-Biotin, PB10011-Cy3, PB10011-Dylight488, PB10011-Dylight550, PB10011-Dylight594, PB10011-FITC, PB10011-HRP, PB10011-APC, PB10011-PE, PB10011-iFluor647, PB10011-carrier-free
Alternative Names	Platelet factor 4
Background	Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4). By in situ hybridization, the CXCL4 gene is mapped to chromosome 4q12-q21. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-PF4 Antibody Picoband® catalog # PB10011. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endotheli
Host	Rabbit
Immunogen Region	E. coli-derived human PF4 recombinant protein (Position: E32-S101). Human PF4 shares 75.4% amino acid (aa) sequence identity with both mouse and rat PF4.
Isotype	Rabbit IgG
Molecular Weight	26 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Platelet factor 4;PF-4;C-X-C motif chemokine 4;Iroplact;Oncostatin-A;Platelet factor 4, short form;PF4;CXCL4, SCYB4;
Tissue Specificity	Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P02776
Gene Id	5196
Gene Name	PF4
Sequence	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, WB
Description	ELISA, 0.1-0.5ug/ml, - Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Eisman, R., Surrey, S., Ramachandran, B., Schwartz, E., Poncz, M. Structural and functional comparison of the genes for human platelet factor 4 and PF4-alt. Blood 76: 336-344, 1990. 2. Griffin, C. A., Emanuel, B. S., LaRocco, P., Schwartz, E., Poncz, M. Human platelet factor 4 gene is mapped to 4q12-q21. Cytogenet. Cell Genet. 45: 67-69, 1987. 3. Lambert, M. P., Rauova, L., Bailey, M., Sola-Visner, M. C., Kowalska, M. A., Poncz, M. Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. Blood 110: 1153-1160, 2007.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000916-1	PB10011	100 ug	-	$370		Add to Cart
BHA21000916-2	PB10011-10ug	10 ug	Sample	$99		Add to Cart
BHA21000916-3	PB10011-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000916-4	PB10011-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000916-5	PB10011-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000916-6	PB10011-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000916-7	PB10011-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000916-8	PB10011-FITC	100 ug	FITC	$570		Add to Cart
BHA21000916-9	PB10011-HRP	100 ug	HRP	$570		Add to Cart
BHA21000916-10	PB10011-APC	100 ug	APC	$670		Add to Cart
BHA21000916-11	PB10011-PE	100 ug	PE	$670		Add to Cart
BHA21000916-12	PB10011-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000916-13	PB10011-carrier-free	100 ug	carrier-free	$370		Add to Cart

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