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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Peroxiredoxin 3/PRDX3 Antibody Picoband®

SKU : BHA21007100

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Mfr.No.	PA1836, PA1836-10ug, PA1836-Biotin, PA1836-Cy3, PA1836-Dylight488, PA1836-Dylight550, PA1836-Dylight594, PA1836-FITC, PA1836-HRP, PA1836-APC, PA1836-PE, PA1836-iFluor647, PA1836-carrier-free
Alternative Names	Thioredoxin-dependent peroxide reductase, mitochondrial
Background	PRDX3 (peroxiredoxin 3) also known as AOP-1, MER5, SP-22 or PRX3, is localized exclusively in mitochondria. The deduced 256-amino acid human AOP1 protein shares 86% amino acid sequence similarity with mouse Aop1, and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23. The PRDX3 gene is mapped on 10q26.11. Expression of PRDX3 is induced by MYC and is reduced in c-myc -/- cells. Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1. Results using mitochondria-specific fluorescent probes demonstrated that PRDX3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells. These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Peroxiredoxin 3/PRDX3 Antibody catalog # PA1836. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of mouse Peroxiredoxin 3, identical to the related rat sequence, and different from the related human sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	26 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Thioredoxin-dependent peroxide reductase, mitochondrial;1.11.1.15;Antioxidant protein 1;AOP-1;PRX III;Perioredoxin-3;Protein MER5;Prdx3;Aop1, Mer5;
Tissue Specificity	Housekeeping-type gene preferentially expressed in murine erythroleukemia (MEL) cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P20108
Gene Name	PRDX3
Sequence	Belongs to the AhpC/TSA family.
Subcellular Location	Mitochondrion .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB, Flow Cytometry
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, By Heat<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry(Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Chiribau, C. B., Cheng, L., Cucoranu, I. C., Yu, Y.-S., Clempus, R. E., Sorescu, D. FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts. J. Biol. Chem. 283: 8211-8217, 2008.<br /><br />2. Nemoto, Y., Yamamoto, T., Takada, S., Matsui, Y., Obinata, M. Antisense RNA of the latent period gene (MER5) inhibits the differentiation of murine erythroleukemia cells. Gene 91: 261-265, 1990. <br /><br />3. Wonsey, D. R., Zeller, K. I., Dang, C. V. The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation. Proc. Nat. Acad. Sci. 99: 6649-6654, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007100-1	PA1836	-	100 ug	$370		Add to Cart
BHA21007100-2	PA1836-10ug	Sample	10 ug	$99		Add to Cart
BHA21007100-3	PA1836-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007100-4	PA1836-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007100-5	PA1836-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007100-6	PA1836-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007100-7	PA1836-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007100-8	PA1836-FITC	FITC	100 ug	$570		Add to Cart
BHA21007100-9	PA1836-HRP	HRP	100 ug	$570		Add to Cart
BHA21007100-10	PA1836-APC	APC	100 ug	$670		Add to Cart
BHA21007100-11	PA1836-PE	PE	100 ug	$670		Add to Cart
BHA21007100-12	PA1836-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007100-13	PA1836-carrier-free	carrier-free	100 ug	$370		Add to Cart

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