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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Peroxiredoxin 1/PRDX1 Antibody Picoband®

SKU : BHA21000245

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Mfr.No.	PB9348, PB9348-10ug, PB9348-Biotin, PB9348-Cy3, PB9348-Dylight488, PB9348-Dylight550, PB9348-Dylight594, PB9348-FITC, PB9348-HRP, PB9348-APC, PB9348-PE, PB9348-iFluor647, PB9348-carrier-free
Alternative Names	Peroxiredoxin-1
Background	PRDX1 (Peroxiredoxin 1), also called PRX1, PAGA or NKEFA, is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The PRDX1 gene is mapped on 1p34.1. Prdx1 was expressed in differentiating motor neuron cells in developing embryonic chicken and mouse spinal cords. mmunoprecipitation analysis showed that GDE2 interacted ly with PRDX1 in embryonic chicken spinal cord extracts and in transfected HEK293T cells. This protein may have a proliferative effect and play a role in cancer development or progression. In differentiating spinal cord, Prdx1 was required to activate Gde2 by reducing an intramolecular cystine bridge between the Gde2 N- and C-terminal domains. An intramolecular disulfide bond between the GDE2 N- and C-terminal domains inhibits GDE2 function, and that reduction of this cystine by PRDX1 activates GDE2 for the induction of motor neuron differentiation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Peroxiredoxin 1/PRDX1 Antibody Picoband® catalog # PB9348. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Peroxiredoxin 1, different from the related mouse sequence by one amino acid, and identical to the related rat sequence.
Isotype	Rabbit IgG
Molecular Weight	24 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Peroxiredoxin-1;1.11.1.15;Natural killer cell-enhancing factor A;NKEF-A;Proliferation-associated gene protein;PAG;Thioredoxin peroxidase 2;Thioredoxin-dependent peroxide reductase 2;PRDX1;PAGA, PAGB, TDPX2;
Tissue Specificity	Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q06830
Gene Id	5052
Gene Name	PRDX1
Sequence	Belongs to the AhpC/TSA family.
Subcellular Location	Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Immunocytochemistry , 0.5-1ug/ml, Human, - Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Neumann, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T., Fujiwara, Y., Orkin, S. H., Van Etten, R. A.Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 424: 561-565, 2003. 2. Prosperi, M.-T., Apiou, F., Dutrillaux, B., Goubin, G. Organization and chromosomal assignment of two human PAG gene loci: PAGA encoding a functional gene and PAGB a processed pseudogene. Genomics 19: 236-241, 1994. 3. Yan, Y., Sabharwal, P., Rao, M., Sockanathan, S. The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2. Cell 138: 1209-1221, 2009.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000245-1	PB9348	100 ug	-	$370		Add to Cart
BHA21000245-2	PB9348-10ug	10 ug	Sample	$99		Add to Cart
BHA21000245-3	PB9348-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000245-4	PB9348-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000245-5	PB9348-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000245-6	PB9348-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000245-7	PB9348-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000245-8	PB9348-FITC	100 ug	FITC	$570		Add to Cart
BHA21000245-9	PB9348-HRP	100 ug	HRP	$570		Add to Cart
BHA21000245-10	PB9348-APC	100 ug	APC	$670		Add to Cart
BHA21000245-11	PB9348-PE	100 ug	PE	$670		Add to Cart
BHA21000245-12	PB9348-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000245-13	PB9348-carrier-free	100 ug	carrier-free	$370		Add to Cart

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