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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PDK2 Antibody Picoband®

SKU : BHA21007224

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Mfr.No.	PA1994, PA1994-10ug, PA1994-Biotin, PA1994-Cy3, PA1994-Dylight488, PA1994-Dylight550, PA1994-Dylight594, PA1994-FITC, PA1994-HRP, PA1994-APC, PA1994-PE, PA1994-iFluor647, PA1994-carrier-free
Alternative Names	(Pyruvate dehydrogenase (acetyl-transferring)) kinase isozyme 2, mitochondrial
Background	PDK2 (Pyruvate Dehydrogenase Kinase Isoenzyme 2), is an enzyme that in humans is encoded by the PDK2 gene. This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alteatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-PDK2 Antibody catalog # PA1994. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human PDK2, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	85-91 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	(Pyruvate dehydrogenase (acetyl-transferring)) kinase isozyme 2, mitochondrial;2.7.11.2;Pyruvate dehydrogenase kinase isoform 2;PDH kinase 2;PDKII;PDK2;PDHK2;
Tissue Specificity	Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q15119
Gene Name	PDK2
Sequence	Belongs to the PDK/BCKDK protein kinase family.
Subcellular Location	Mitochondrion matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, ICC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat <br>Immunocytochemistry , 0.5-1ug/ml, Human, Mouse, Rat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Gudi, R., Bowker-Kinley, M. M., Kedishvili, N. Y., Zhao, Y., Popov, K. M. Diversity of the pyruvate dehydrogenase kinase gene family in humans. J. Biol. Chem. 270: 28989-28994, 1995.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007224-1	PA1994	-	100 ug	$370		Add to Cart
BHA21007224-2	PA1994-10ug	Sample	10 ug	$99		Add to Cart
BHA21007224-3	PA1994-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007224-4	PA1994-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007224-5	PA1994-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007224-6	PA1994-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007224-7	PA1994-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007224-8	PA1994-FITC	FITC	100 ug	$570		Add to Cart
BHA21007224-9	PA1994-HRP	HRP	100 ug	$570		Add to Cart
BHA21007224-10	PA1994-APC	APC	100 ug	$670		Add to Cart
BHA21007224-11	PA1994-PE	PE	100 ug	$670		Add to Cart
BHA21007224-12	PA1994-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007224-13	PA1994-carrier-free	carrier-free	100 ug	$370		Add to Cart

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